Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Identification of two distinct pathways of human myelopoiesis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Neutrophils at work

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Vitamin D controls T cell antigen receptor signaling and activation of human T cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Cellular origin of prognostic chromosomal aberrations in AML patients

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Human myelopoiesis has been proposed to occur through oligopotent common myeloid progenitor (CMP) and lymphoid-primed multipotent progenitor (LMPP) populations. However, other studies have proposed direct commitment of multipotent cells to unilineage fates, without specific intermediary lineage cosegregation patterns. We here show that distinct human myeloid progenitor populations generate the neutrophil/monocyte and mast cell/basophil/eosinophil lineages as previously shown in mouse. Moreover, we find that neutrophil/monocyte potential selectively cosegregates with lymphoid lineage and mast cell/basophil/eosinophil potentials with megakaryocyte/erythroid potential early during lineage commitment. Furthermore, after this initial commitment step, mast cell/basophil/eosinophil and megakaryocyte/erythroid potentials colocalize at the single-cell level in restricted oligopotent progenitors. These results show that human myeloid lineages are generated through two distinct cellular pathways defined by complementary oligopotent cell populations.

Original languageEnglish
JournalNature Immunology
Volume4
Issue number35
ISSN1529-2908
DOIs
Publication statusPublished - 24 May 2019

ID: 57298388