Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The trans-ancestral genomic architecture of glycemic traits

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Genetic analyses identify widespread sex-differential participation bias

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Coagulation parameters in the newborn and infant - the Copenhagen Baby Heart and COMPARE studies

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Lipoprotein(a) levels at birth and in early childhood: The COMPARE Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Triglyceride-rich Lipoprotein Cholesterol (Remnant Cholesterol) as a Therapeutic Target for Cardiovascular Disease Risk

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  4. A possible explanation for the contrasting results of REDUCE-IT vs. STRENGTH: cohort study mimicking trial designs

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Wei Zhao
  • Asif Rasheed
  • Emmi Tikkanen
  • Jung-Jin Lee
  • Adam S Butterworth
  • Joanna M M Howson
  • Themistocles L Assimes
  • Rajiv Chowdhury
  • Marju Orho-Melander
  • Scott Damrauer
  • Aeron Small
  • Senay Asma
  • Minako Imamura
  • Toshimasa Yamauch
  • John C Chambers
  • Peng Chen
  • Bishwa R Sapkota
  • Nabi Shah
  • Sehrish Jabeen
  • Praveen Surendran
  • Yingchang Lu
  • Weihua Zhang
  • Atif Imran
  • Shahid Abbas
  • Faisal Majeed
  • Kevin Trindade
  • Nadeem Qamar
  • Nadeem Hayyat Mallick
  • Zia Yaqoob
  • Tahir Saghir
  • Syed Nadeem Hasan Rizvi
  • Anis Memon
  • Syed Zahed Rasheed
  • Fazal-Ur-Rehman Memon
  • Khalid Mehmood
  • Naveeduddin Ahmed
  • Irshad Hussain Qureshi
  • Tanveer-Us-Salam
  • Wasim Iqbal
  • Uzma Malik
  • Narinder Mehra
  • Jane Z Kuo
  • Wayne H-H Sheu
  • Xiuqing Guo
  • Sune F Nielsen
  • Børge G Nordestgaard
  • Anne Tybjaerg-Hansen
  • Marianne Benn
  • Ruth Frikke-Schmidt
  • Pia R Kamstrup
  • CHD Exome+ Consortium
View graph of relations

To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLA-DRB5 (odds ratio (OR) = 1.29). We show that genetically mediated increase in T2D risk also confers higher CHD risk. Joint T2D-CHD analysis identified eight variants-two of which are coding-where T2D and CHD associations appear to colocalize, including a new joint T2D-CHD association at the CCDC92 locus that also replicated for T2D. The variants associated with both outcomes implicate new pathways as well as targets of existing drugs, including icosapent ethyl and adipocyte fatty-acid-binding protein.

Original languageEnglish
JournalNature Genetics
Volume49
Issue number10
Pages (from-to)1450-1457
Number of pages8
ISSN1061-4036
DOIs
Publication statusPublished - Oct 2017

    Research areas

  • Asia, Asian Continental Ancestry Group, Biomarkers, Comorbidity, Coronary Disease, Diabetes Mellitus, Type 2, Europe, European Continental Ancestry Group, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, HLA-DRB5 Chains, Humans, Metabolic Networks and Pathways, Metabolic Syndrome, Molecular Targeted Therapy, Mutation, Missense, Polymorphism, Single Nucleotide, Risk Factors, Comparative Study, Journal Article

ID: 52188462