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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Identification of new sensitive biomarkers for the in vivo response to interferon-beta treatment in multiple sclerosis using DNA-array evaluation

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  1. Randomized trial of facilitated subcutaneous immunoglobulin in multifocal motor neuropathy

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  2. Acute endovascular reperfusion treatment in patients with ischaemic stroke and large-vessel occlusion (Denmark 2011–2017)

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  3. Disturbed sleep in cluster headache is not the result of transient processes associated with the cluster period

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  4. Early versus later treatment start in multiple sclerosis: a register-based cohort study

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  5. Ictal and interictal electric source imaging in presurgical evaluation: a prospective study

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  1. Diagnostic value of oligoclonal bands in children: A Nationwide Population-Based Cohort Study

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  2. Smoking is associated with increased disease activity during natalizumab treatment in multiple sclerosis

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  3. Functional neuroimaging of recovery from motor conversion disorder: A case report

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Neutralizing antibodies (NAbs) occur in a proportion of multiple sclerosis (MS) patients treated with interferon (IFN)-beta. NAbs impair the effect of treatment. The biological effect of IFN-beta can be measured as the induction of the myxovirus resistance protein A (MxA) molecule. However, other markers could be more sensitive for evaluating the response to IFN-beta. We used DNA array analysis to identify genes that are strongly induced in blood cells by IFN-beta, and measured their expression in MS patients with different NAb levels.
Original languageEnglish
JournalEuropean Journal of Neurology
Volume16
Issue number12
Pages (from-to)1291-8
Number of pages8
ISSN1351-5101
DOIs
Publication statusPublished - 2009

    Research areas

  • Antibodies, Neutralizing, Biological Markers, Chemokine CCL2, Chemokine CXCL10, Drug Resistance, Gene Expression, Gene Expression Profiling, Humans, Immunologic Factors, Interferon-beta, Membrane Proteins, Multiple Sclerosis, Oligonucleotide Array Sequence Analysis, Reverse Transcriptase Polymerase Chain Reaction

ID: 33228103