Identification of coumarin as the sensitizer in a patient sensitive to her own perfume but negative to the fragrance mix

V Mutterer; Elena Gimenéz-Arnau; J P Lepoittevin; J D Johansen; Peter J Frosch; T Menné; K E Andersen; M Bruze; Suresh Chandra Rastogi; I R White

Identification of coumarin as the sensitizer in a patient sensitive to her own perfume but negative to the fragrance mix

V Mutterer, Elena Gimenéz-Arnau, J P Lepoittevin, J D Johansen, Peter J Frosch, T Menné, K E Andersen, M Bruze, Suresh Chandra Rastogi, I R White

Dermatology and Allergy

22 Citations (Scopus)

Abstract

The aim of this study was to identify the chemicals responsible for the sensitivity of a 44-year-old woman to her own perfume, but showing negative patch test results to the fragrance mix. For this purpose, the perfume concentrate from the eau de toilette was chemically fractionated. Each fraction obtained was afterwards tested on the patient using a ROAT and/or a patch test. Only 1 fraction gave a positive ROAT result. This fraction was analyzed and found to contain coumarin and ethyl vanillin. Coumarin, one of the most widely used fragrance compounds that is not present in the fragrance mix, was confirmed as being the sensitizer.

Original language	English
Journal	Contact Dermatitis
Volume	40
Issue number	4
Pages (from-to)	196-9
Number of pages	4
ISSN	0105-1873
Publication status	Published - Apr 1999

Keywords

Adult
Cosmetics
Coumarins
Dermatitis, Allergic Contact
Female
Humans
Patch Tests
Perfume
Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Cite this

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title = "Identification of coumarin as the sensitizer in a patient sensitive to her own perfume but negative to the fragrance mix",

abstract = "The aim of this study was to identify the chemicals responsible for the sensitivity of a 44-year-old woman to her own perfume, but showing negative patch test results to the fragrance mix. For this purpose, the perfume concentrate from the eau de toilette was chemically fractionated. Each fraction obtained was afterwards tested on the patient using a ROAT and/or a patch test. Only 1 fraction gave a positive ROAT result. This fraction was analyzed and found to contain coumarin and ethyl vanillin. Coumarin, one of the most widely used fragrance compounds that is not present in the fragrance mix, was confirmed as being the sensitizer.",

keywords = "Adult, Cosmetics, Coumarins, Dermatitis, Allergic Contact, Female, Humans, Patch Tests, Perfume, Case Reports, Journal Article, Research Support, Non-U.S. Gov't",

author = "V Mutterer and Elena Gimen{\'e}z-Arnau and Lepoittevin, \{J P\} and Johansen, \{J D\} and Frosch, \{Peter J\} and T Menn{\'e} and Andersen, \{K E\} and M Bruze and Rastogi, \{Suresh Chandra\} and White, \{I R\}",

year = "1999",

month = apr,

language = "English",

volume = "40",

pages = "196--9",

journal = "Contact Dermatitis",

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TY - JOUR

T1 - Identification of coumarin as the sensitizer in a patient sensitive to her own perfume but negative to the fragrance mix

AU - Mutterer, V

AU - Gimenéz-Arnau, Elena

AU - Lepoittevin, J P

AU - Johansen, J D

AU - Frosch, Peter J

AU - Menné, T

AU - Andersen, K E

AU - Bruze, M

AU - Rastogi, Suresh Chandra

AU - White, I R

PY - 1999/4

Y1 - 1999/4

N2 - The aim of this study was to identify the chemicals responsible for the sensitivity of a 44-year-old woman to her own perfume, but showing negative patch test results to the fragrance mix. For this purpose, the perfume concentrate from the eau de toilette was chemically fractionated. Each fraction obtained was afterwards tested on the patient using a ROAT and/or a patch test. Only 1 fraction gave a positive ROAT result. This fraction was analyzed and found to contain coumarin and ethyl vanillin. Coumarin, one of the most widely used fragrance compounds that is not present in the fragrance mix, was confirmed as being the sensitizer.

AB - The aim of this study was to identify the chemicals responsible for the sensitivity of a 44-year-old woman to her own perfume, but showing negative patch test results to the fragrance mix. For this purpose, the perfume concentrate from the eau de toilette was chemically fractionated. Each fraction obtained was afterwards tested on the patient using a ROAT and/or a patch test. Only 1 fraction gave a positive ROAT result. This fraction was analyzed and found to contain coumarin and ethyl vanillin. Coumarin, one of the most widely used fragrance compounds that is not present in the fragrance mix, was confirmed as being the sensitizer.

KW - Adult

KW - Cosmetics

KW - Coumarins

KW - Dermatitis, Allergic Contact

KW - Female

KW - Humans

KW - Patch Tests

KW - Perfume

KW - Case Reports

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

UR - https://www.scopus.com/pages/publications/0032971811

M3 - Journal article

C2 - 10208506

SN - 0105-1873

VL - 40

SP - 196

EP - 199

JO - Contact Dermatitis

JF - Contact Dermatitis

IS - 4

ER -

Identification of coumarin as the sensitizer in a patient sensitive to her own perfume but negative to the fragrance mix

Abstract

Keywords

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