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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Improved skeletal muscle mass and strength after heavy strength training in very old individuals

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  1. Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma

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  2. Regulation of apoptosis and autophagy in mouse and human skeletal muscle with aging and lifelong exercise training

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  3. Can electrical stimulation enhance effects of a functional training program in hospitalized geriatric patients?

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  4. Plasticity in central neural drive with short-term disuse and recovery - effects on muscle strength and influence of aging

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  5. Handgrip strength shows no improvements in geriatric patients with persistent inflammation during hospitalization

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  1. Postprandial Nutrient Handling and Gastrointestinal Hormone Secretion After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy

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  2. Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease

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  3. Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise

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Age-related loss of muscle mass and function represents personal and socioeconomic challenges. The purpose of this study was to determine the adaptation of skeletal musculature in very old individuals (83+ years) performing 12weeks of heavy resistance training (3×/week) (HRT) compared to a non-training control group (CON). Both groups received similar protein supplementations. We studied 26 participants (86.9±3.2 (SD) (83-94, range) years old) per-protocol. Quadriceps cross-sectional area (CSA) differed between groups at post-test (P<0.05) and increased 1.5±0.7cm2 (3.4%) (P<0.05) in HRT only. The increase in CSA is correlated inversely with the baseline level of CSA (R2=0.43, P<0.02). Thigh muscle isometric strength, isokinetic peak torque and power increased significantly only in HRT by 10-15%, whereas knee extension one-repetition maximum (1 RM) improved by 91%. Physical functional tests, muscle fiber type distribution and size did not differ significantly between groups. We conclude that in protein supplemented very old individuals, heavy resistance training can increase muscle mass and strength, and that the relative improvement in mass is more pronounced when initial muscle mass is low.

Original languageEnglish
JournalExperimental Gerontology
Volume92
Pages (from-to)96-105
Number of pages10
ISSN0531-5565
DOIs
Publication statusPublished - Jun 2017

    Research areas

  • Adaptation, Physiological, Aged, 80 and over, Aging, Blood Pressure, Denmark, Female, Humans, Linear Models, Male, Muscle Fibers, Skeletal, Muscle Strength, Organ Size, Quadriceps Muscle, Resistance Training, Treatment Outcome, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

ID: 52387084