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Gene expression profile of colon cancer cell lines treated with SN-38

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Colorectal cancer is the third most common form of cancer in the industrial countries. Due to advances regarding the treatments, primarily development of improved surgical methods and the ability to make the earlier diagnosis, the mortality has remained constant during the past decades even though the incidence in fact has increased. To improve chemotherapy and enable personalised treatment, the need of biomarkers is of great significance. In this study, we evaluated the gene expression profiles of the colon cancer cell lines treated with SN-38, the active metabolite of topoisomerase-1 inhibitor irinotecan which leads to cell cycle arrest and apoptosis.
Original languageEnglish
JournalChemotherapy
Volume56
Issue number1
Pages (from-to)17-25
Number of pages8
DOIs
Publication statusPublished - 2010

    Research areas

  • Antineoplastic Agents, Phytogenic, Camptothecin, Cell Line, Tumor, Colonic Neoplasms, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Oligonucleotide Array Sequence Analysis

ID: 32547319