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The Capital Region of Denmark - a part of Copenhagen University Hospital
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RNA profiling reveals familial aggregation of molecular subtypes in non-BRCA1/2 breast cancer families

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  1. Pediatric cancer families' participation in whole-genome sequencing research in Denmark: Parent perspectives

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  2. En familie med nedarvet DICER1-mutation

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  3. Kræftdisponerende mutationer er hyppige hos børn og unge med kræft

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  4. Is DBCG abreast of new developments?

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  5. Clinical and molecular characterization of BRCA-associated breast cancer: results from the DBCG

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  • Martin Jakob Larsen
  • Mads Thomassen
  • Qihua Tan
  • Anne-Vibeke Lænkholm
  • Martin Bak
  • Kristina Pilekær Sørensen
  • Mette Klarskov Andersen
  • Torben A Kruse
  • Anne-Marie Gerdes
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In more than 70% of families with a strong history of breast and ovarian cancers, pathogenic mutation in BRCA1 or BRCA2 cannot be identified, even though hereditary factors are expected to be involved. It has been proposed that tumors with similar molecular phenotypes also share similar underlying pathophysiological mechanisms. In the current study, the aim was to investigate if global RNA profiling can be used to identify functional subgroups within breast tumors from families tested negative for BRCA1/2 germline mutations and how these subgroupings relate to different breast cancer patients within the same family.
Original languageEnglish
JournalB M C Medical Genomics
Volume7
Issue number1
Pages (from-to)9
ISSN1755-8794
DOIs
StatePublished - 2014

ID: 42915567