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The prevalence and morbidity of sensitization to fragrance mix I in the general population

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BACKGROUND: The prevalence of sensitization to fragrance mix (FM) I and Myroxylon pereirae (MP, balsam of Peru) has decreased in recent years among Danish women with dermatitis.

OBJECTIVES: This study investigated whether the decrease could be confirmed among women in the general population. Furthermore, it addressed the morbidity of FM I sensitization.

METHODS: In 1990, 1998 and 2006, 4299 individuals aged 18-69 years (18-41 years only in 1998) completed a premailed questionnaire and were patch tested to FM I and MP. Data were analysed by logistic regression analyses and associations were expressed as odds ratios (ORs) with 95% confidence intervals (CIs).

RESULTS: The prevalence of FM I and MP sensitization followed an inverted V-pattern among women aged 18-41 years (i.e. an increase from 1990 to 1998, followed by a decrease from 1998 to 2006). Logistic regression analyses showed that 'medical consultation due to cosmetic dermatitis' (OR 3.37, 95% CI 1.83-6.20) and 'cosmetic dermatitis within the past 12 months' (OR 3.53, CI 2.02-6.17) were significantly associated with sensitization to FM I.

CONCLUSIONS: In line with trends observed in Danish patients with dermatitis, our results supported a recent decrease in the prevalence of FM I and MP sensitization in Denmark. The study also showed that fragrance sensitization was associated with self-reported cosmetic dermatitis and use of health care related to cosmetic dermatitis.

Original languageEnglish
JournalBritish Journal of Dermatology
Volume161
Issue number1
Pages (from-to)95-101
Number of pages7
ISSN0007-0963
DOIs
Publication statusPublished - Jul 2009

    Research areas

  • Adolescent, Adult, Aged, Balsams, Denmark, Dermatitis, Allergic Contact, Female, Humans, Logistic Models, Male, Middle Aged, Myroxylon, Patch Tests, Perfume, Plant Preparations, Prevalence, Young Adult, Journal Article, Research Support, Non-U.S. Gov't

ID: 51602703