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The Capital Region of Denmark - a part of Copenhagen University Hospital

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

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  • John Burn
  • Anne-Marie Axø Gerdes
  • Finlay Macrae
  • Jukka-Pekka Mecklin
  • Gabriela Moeslein
  • Sylviane Olschwang
  • Diane Eccles
  • D Gareth Evans
  • Eamonn R Maher
  • Lucio Bertario
  • Marie-Luise Bisgaard
  • Malcolm G Dunlop
  • Judy W C Ho
  • Shirley V Hodgson
  • Annika Lindblom
  • Jan Lubinski
  • Patrick J Morrison
  • Victoria Murday
  • Raj Ramesar
  • Lucy Side
  • Rodney J Scott
  • Huw J W Thomas
  • Hans F Vasen
  • Gail Barker
  • Gillian Crawford
  • Faye Elliott
  • Mohammad Movahedi
  • Kirsi Pylvanainen
  • Juul T Wijnen
  • Riccardo Fodde
  • Henry T Lynch
  • John C Mathers
  • D Timothy Bishop
  • CAPP2 Investigators
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Observational studies report reduced colorectal cancer in regular aspirin consumers. Randomised controlled trials have shown reduced risk of adenomas but none have employed prevention of colorectal cancer as a primary endpoint. The CAPP2 trial aimed to investigate the antineoplastic effects of aspirin and a resistant starch in carriers of Lynch syndrome, the major form of hereditary colorectal cancer; we now report long-term follow-up of participants randomly assigned to aspirin or placebo.
Original languageEnglish
Issue number9809
Pages (from-to)2081-7
Number of pages7
Publication statusPublished - 2011

    Research areas

  • Adenoma, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Chemoprevention, Colorectal Neoplasms, Hereditary Nonpolyposis, Dietary Carbohydrates, Double-Blind Method, Heterozygote, Humans, Starch

ID: 33281438