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The Capital Region of Denmark - a part of Copenhagen University Hospital
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The KCNE genes in hypertrophic cardiomyopathy: a candidate gene study

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The gene family KCNE1-5, which encode modulating β-subunits of several repolarising K+-ion channels, has been associated with genetic cardiac diseases such as long QT syndrome, atrial fibrillation and Brugada syndrome. The minK peptide, encoded by KCNE1, is attached to the Z-disc of the sarcomere as well as the T-tubules of the sarcolemma. It has been suggested that minK forms part of an "electro-mechanical feed-back" which links cardiomyocyte stretching to changes in ion channel function. We examined whether mutations in KCNE genes were associated with hypertrophic cardiomyopathy (HCM), a genetic disease associated with an improper hypertrophic response.
Original languageEnglish
JournalJournal of Negative Results in BioMedicine
Volume10
Pages (from-to)12
ISSN1477-5751
DOIs
Publication statusPublished - 2011

ID: 33264968