Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Effects of postnatal anoxia on striatal dopamine metabolism and prepulse inhibition in rats

Research output: Contribution to journalJournal articleResearchpeer-review

  1. The glucagon-like peptide 1 receptor agonist Exendin-4 decreases relapse-like drinking in socially housed mice

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Tesofensine induces appetite suppression and weight loss with reversal of low forebrain dopamine levels in the diet-induced obese rat

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Neuropeptide Y Y5 receptor antagonism causes faster extinction and attenuates reinstatement in cocaine-induced place preference

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Can Animal Models of Copy Number Variants That Predispose to Schizophrenia Elucidate Underlying Biology?

    Research output: Contribution to journalReviewResearchpeer-review

  2. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. AMPK signaling linked to the schizophrenia-associated 1q21.1 deletion is required for neuronal and sleep maintenance

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Complex spatio-temporal distribution and genomic ancestry of mitochondrial DNA haplogroups in 24,216 Danes

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Karin Sandager-Nielsen
  • Maibritt B Andersen
  • Thomas N Sager
  • Thomas Werge
  • Jørgen Scheel-Krüger
View graph of relations
Various evidence indicate that schizophrenia is a neurodevelopmental disorder. Epidemiological observations point to oxygen deficiencies during delivery as one of the early risk factors for developing schizophrenia. The aim of the present study was to examine the effect of postnatal anoxia in rats. Anoxia was experimentally induced by placing 9-day-old rat pups for 6 min in a chamber saturated with 100% nitrogen (N(2)). Exposure to anoxia on postnatal day (PND) 9 resulted in significantly reduced subcortical dopamine metabolism and turnover, as measured by striatal 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) concentrations. Furthermore, in the anoxic group only, striatal HVA concentrations were negatively correlated to prefrontal cortical N-acetylaspartate (NAA) levels. Similar findings of distorted prefrontal-subcortical interactions have recently been reported in schizophrenic patients. There was no effect of postnatal anoxia on either baseline or d-amphetamine-induced deficit in the prepulse inhibition (PPI) paradigm in adulthood. Accordingly, although oxygen deficiency early in life has been discussed as vulnerability factor in developing schizophrenia, exposure to postnatal anoxia in the rat does not show clear-cut phenomenological similarities with the disorder.
Original languageEnglish
JournalPharmacology, Biochemistry and Behavior
Volume77
Issue number4
Pages (from-to)767-74
Number of pages8
ISSN0091-3057
DOIs
StatePublished - 2004

    Research areas

  • Age Factors, Animals, Animals, Newborn, Corpus Striatum, Dopamine, Female, Hypoxia, Brain, Male, Rats, Rats, Wistar, Startle Reaction

ID: 36913053