Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Impact of bone graft harvesting techniques on bone formation and graft resorption: a histomorphometric study in the mandibles of minipigs

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Adverse reaction after hyaluronan injection for minimally invasive papilla volume augmentation. A report on two cases

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Pectin nanocoating of titanium implant surfaces - an experimental study in rabbits

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Clinical and radiographic evaluation of early loaded narrow-diameter implants: 3 years follow-up

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Adverse reaction after hyaluronan injection for minimally invasive papilla volume augmentation. A report on two cases

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Autoreferat af doktordisputats. Materialer til knogleopbygning. Dyreeksperimentelle undersøgelser

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Bone grafting materials in bone repair: Experimental studies

    Research output: Book/ReportDoctoral thesisResearch

  4. Selecting biomaterials for implant procedures

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  • Nikola Saulacic
  • Dieter D Bosshardt
  • Simon S Jensen
  • Richard J Miron
  • Reinhard Gruber
  • Daniel Buser
View graph of relations

BACKGROUND: Harvesting techniques can affect cellular parameters of autogenous bone grafts in vitro. Whether these differences translate to in vivo bone formation, however, remains unknown.

OBJECTIVE: The purpose of this study was to assess the impact of different harvesting techniques on bone formation and graft resorption in vivo.

MATERIAL AND METHODS: Four harvesting techniques were used: (i) corticocancellous blocks particulated by a bone mill; (ii) bone scraper; (iii) piezosurgery; and (iv) bone slurry collected from a filter device upon drilling. The grafts were placed into bone defects in the mandibles of 12 minipigs. The animals were sacrificed after 1, 2, 4 and 8 weeks of healing. Histology and histomorphometrical analyses were performed to assess bone formation and graft resorption. An explorative statistical analysis was performed.

RESULTS: The amount of new bone increased, while the amount of residual bone decreased over time with all harvesting techniques. At all given time points, no significant advantage of any harvesting technique on bone formation was observed. The harvesting technique, however, affected bone formation and the amount of residual graft within the overall healing period. Friedman test revealed an impact of the harvesting technique on residual bone graft after 2 and 4 weeks. At the later time point, post hoc testing showed more newly formed bone in association with bone graft processed by bone mill than harvested by bone scraper and piezosurgery.

CONCLUSIONS: Transplantation of autogenous bone particles harvested with four techniques in the present model resulted in moderate differences in terms of bone formation and graft resorption.

Original languageEnglish
JournalClinical Oral Implants Research
Volume26
Issue number4
Pages (from-to)383-91
Number of pages9
ISSN0905-7161
DOIs
StatePublished - Apr 2015

ID: 46231161