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Use of intracranial pressure monitoring in bacterial meningitis: a 10-year follow up on outcome and intracranial pressure versus head CT scans

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  • Lykke Larsen
  • Frantz R Poulsen
  • Troels Halfeld Nielsen
  • Carl-Henrik Nordström
  • Mette K Schulz
  • Åse B Andersen
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BACKGROUND: The aim of this study was to evaluate the clinical outcome of patients with severe bacterial meningitis where intracranial pressure (ICP) monitoring has been performed.

METHODS: A retrospective observational study including patients admitted 1st. January 2005 to 31st. December 2014. Thirty nine patients age 18-89 years were included. All the patients received intensive care with mechanical ventilation, ICP monitoring, sedation, antibiotics and corticosteroids according to current guidelines. Clinical outcome was defined as death during hospitalization or survival at hospital discharge.

RESULTS: The most common pathogen was Streptococcus pneumoniae (26; 67%). Thirteen patients died (33%) and neurologic impairment was noted in twenty two (84.6%) surviving patients. In S. pneumoniae cases patients with adverse outcome were significantly older (p = 0.0024) and immunosuppressed (p = 0.034). Lower mean-cerebral perfusion pressure (CPP) was found to correlate with adverse outcome (p = 0.005). Cerebrospinal fluid (CSF) was drained in fourteen patients. Increased ICP (>20 mmHg) was observed in twenty four patients. No significant correlation was found between measured ICP and head CT scans with signs of elevated ICP.

CONCLUSIONS: Patients with severe meningitis should be admitted to intensive care units and evaluated for ICP monitoring regardless of head CT findings.

Original languageEnglish
JournalInfectious diseases (London, England)
Volume49
Issue number5
Pages (from-to)356-364
Number of pages9
ISSN2374-4235
DOIs
Publication statusPublished - May 2017

    Research areas

  • Adolescent, Adult, Aged, Aged, 80 and over, Drug Monitoring, Female, Head, Humans, Intracranial Pressure, Male, Meningitis, Bacterial, Middle Aged, Retrospective Studies, Survival Analysis, Tomography, X-Ray Computed, Treatment Outcome, Young Adult, Journal Article, Observational Study

ID: 52591724