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Impact of xanthohumol (a prenylated flavonoid from hops) on DNA stability and other health-related biochemical parameters: Results of human intervention trials

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  • Franziska Ferk
  • Miroslav Mišík
  • Armen Nersesyan
  • Christoph Pichler
  • Walter Jäger
  • Thomas Szekeres
  • Rodrig Marculescu
  • Henrik E Poulsen
  • Trine Henriksen
  • Roberto Bono
  • Valeria Romanazzi
  • Halh Al-Serori
  • Martin Biendl
  • Karl-Heinz Wagner
  • Michael Kundi
  • Siegfried Knasmüller
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SCOPE: Xanthohumol (XN) is a hop flavonoid found in beers and refreshment drinks. Results of in vitro and animal studies indicate that it causes beneficial health effects due to DNA protective, anti-inflammatory, antioxidant, and phytoestrogenic properties. Aim of the present study was to find out if XN causes alterations of health-related parameters in humans.

METHODS AND RESULTS: The effects of the flavonoid were investigated in a randomized crossover intervention trial (n = 22) in which the participants consumed a XN drink (12 mg XN/P/day). We monitored alterations of the DNA stability in single cell gel electrophoresis assays in lymphocytes and of several health-related biomarkers. A decrease of oxidatively damaged purines and protection toward reactive oxygen species induced DNA damage was found after the consumption of the beverage; also the excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-guanosine in urine was reduced. The assumption that the flavonoid causes DNA protection was confirmed in a randomized follow-up study with pure XN (n = 10) with a parallel design. Other biochemical parameters reflecting the redox- and hormonal status and lipid- and glucose metabolism were not altered after the intervention.

CONCLUSION: Taken together, our data indicate that low doses of XN protect humans against oxidative DNA damage.

Original languageEnglish
JournalMolecular Nutrition & Food Research
Volume60
Issue number4
Pages (from-to)773-86
Number of pages14
ISSN1613-4125
DOIs
Publication statusPublished - Apr 2016

    Research areas

  • Journal Article, Research Support, Non-U.S. Gov't

ID: 49512765