Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Muscles and their myokines

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. The thick left ventricular wall of the giraffe heart normalises wall tension, but limits stroke volume and cardiac output

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Epicardial and pericardial adipose tissues are associated with reduced diastolic and systolic function in type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Exercise-mediated improvement of depression in patients with gastro-esophageal junction cancer is linked to kynurenine metabolism

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. A multisystem composite biomarker as a preliminary diagnostic test in bipolar disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
In the past, the role of physical activity as a life-style modulating factor has been considered as that of a tool to balance energy intake. Although it is important to avoid obesity, physical inactivity should be discussed in a much broader context. There is accumulating epidemiological evidence that a physically active life plays an independent role in the protection against type 2 diabetes, cardiovascular diseases, cancer, dementia and even depression. For most of the last century, researchers sought a link between muscle contraction and humoral changes in the form of an 'exercise factor', which could be released from skeletal muscle during contraction and mediate some of the exercise-induced metabolic changes in other organs such as the liver and the adipose tissue. We have suggested that cytokines or other peptides that are produced, expressed and released by muscle fibres and exert autocrine, paracrine or endocrine effects should be classified as 'myokines'. Given that skeletal muscle is the largest organ in the human body, our discovery that contracting skeletal muscle secretes proteins sets a novel paradigm: skeletal muscle is an endocrine organ producing and releasing myokines, which work in a hormone-like fashion, exerting specific endocrine effects on other organs. Other myokines work via paracrine mechanisms, exerting local effects on signalling pathways involved in muscle metabolism. It has been suggested that myokines may contribute to exercise-induced protection against several chronic diseases.
Original languageEnglish
JournalJournal of Experimental Biology
Volume214
Issue numberPt 2
Pages (from-to)337-46
Number of pages10
ISSN0022-0949
DOIs
Publication statusPublished - 2011

    Research areas

  • Adipose Tissue, Animals, Cardiovascular Diseases, Chronic Disease, Cytokines, Diabetes Mellitus, Type 2, Exercise, Humans, Interleukin-6, Motor Activity, Muscle, Skeletal, Neoplasms, Neurodegenerative Diseases

ID: 33271518