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The Capital Region of Denmark - a part of Copenhagen University Hospital
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The role of dexamethasone in the treatment of bacterial meningitis - a systematic review

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  1. External validation of the Simplified Mortality Score for the Intensive Care Unit (SMS-ICU)

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  2. Inadequate emergence after non-cardiac surgery-A prospective observational study in 1000 patients

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  3. Lower vs higher transfusion threshold in septic shock patients of different ages: A study protocol

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  4. Performance of SAPS II according to ICU length of stay: A Danish nationwide cohort study

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  5. Effects of simulated sample sizes on mortality estimates-Protocol for a study in 3 randomised ICU trials

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  1. Aneurismal subaraknoidalblødning

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  2. Delirium assessment in neuro-critically ill patients: A validation study

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  3. Intracranial pressure during hemodialysis in patients with acute brain injury

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Corticosteroids are used as an adjunct to antibiotics in the treatment of bacterial meningitis in an attempt to attenuate the intrathecal inflammatory response and thereby reduce mortality and morbidity. The purpose of the present paper is to provide a review of clinical studies of corticosteroids in the treatment of bacterial meningitis. Relevant literature was found in PubMed, the Cochrane databases, and references in studies. Forty-four publications of relevance were identified, comprising 29 publications of randomised studies, 10 publications reporting either non- or quasi-randomised studies, and five reporting retrospective studies, and nine meta-analyses. Taken together, dexamethasone treatment may be associated with a lower mortality in adults and fewer neurological and auditory sequelae in adults and children from high-income countries, in particular in adults suffering from pneumococcal meningitis. In contrast, studies conducted in developing countries have yielded less favourable results.
Original languageEnglish
JournalActa Anaesthesiologica Scandinavica
Volume56
Issue number10
Pages (from-to)1210-21
Number of pages12
ISSN0001-5172
DOIs
Publication statusPublished - 2012

ID: 36494078