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The Capital Region of Denmark - a part of Copenhagen University Hospital
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The role of dexamethasone in the treatment of bacterial meningitis - a systematic review

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  1. Maintaining Competence in Airway Management

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  2. The handling oxygenation targets in the intensive care unit (HOT-ICU) trial: Detailed statistical analysis plan

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  3. Impact of Physician-staffed Helicopters on Pre-hospital Patient Outcomes: a systematic review

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  1. Hypozincaemia is associated with severity of aneurysmal subarachnoid haemorrhage: a retrospective cohort study

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  2. Continuous EEG Monitoring in a Consecutive Patient Cohort with Sepsis and Delirium

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  3. Transcerebral exchange kinetics of large neutral amino acids during acute inspiratory hypoxia in humans

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  4. Delayed cerebral ischaemia in patients with aneurysmal subarachnoid haemorrhage: Functional outcome and long-term mortality

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  5. Soluble ST2 links inflammation to outcome after subarachnoid hemorrhage

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Corticosteroids are used as an adjunct to antibiotics in the treatment of bacterial meningitis in an attempt to attenuate the intrathecal inflammatory response and thereby reduce mortality and morbidity. The purpose of the present paper is to provide a review of clinical studies of corticosteroids in the treatment of bacterial meningitis. Relevant literature was found in PubMed, the Cochrane databases, and references in studies. Forty-four publications of relevance were identified, comprising 29 publications of randomised studies, 10 publications reporting either non- or quasi-randomised studies, and five reporting retrospective studies, and nine meta-analyses. Taken together, dexamethasone treatment may be associated with a lower mortality in adults and fewer neurological and auditory sequelae in adults and children from high-income countries, in particular in adults suffering from pneumococcal meningitis. In contrast, studies conducted in developing countries have yielded less favourable results.
Original languageEnglish
JournalActa Anaesthesiologica Scandinavica
Volume56
Issue number10
Pages (from-to)1210-21
Number of pages12
ISSN0001-5172
DOIs
Publication statusPublished - 2012

ID: 36494078