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The Capital Region of Denmark - a part of Copenhagen University Hospital
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The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Hepatocellular carcinoma in patients with chronic hepatitis C and cirrhosis in Denmark: a nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Historical epidemiology of hepatitis C virus (HCV) in selected countries

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Strategies to manage hepatitis C virus (HCV) disease burden

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  4. Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Diagnostic performance of clinical characteristics to detect airflow limitation in people living with HIV and in uninfected controls

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  2. HIV Status Is a Greater Determinant of Low Self-perceived Life Expectancy Than Cigarette Smoking in a Well-resourced Setting

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  3. Outcome and adverse events in patients with chronic hepatitis C treated with direct-acting antivirals: A clinical randomized study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • H Razavi
  • I Waked
  • C Sarrazin
  • R P Myers
  • R Idilman
  • F Calinas
  • W Vogel
  • M C Mendes Correa
  • C Hézode
  • P Lázaro
  • U Akarca
  • S Aleman
  • I Balık
  • T Berg
  • F Bihl
  • M Bilodeau
  • A J Blasco
  • C E Brandão Mello
  • P Bruggmann
  • M Buti
  • J L Calleja
  • H Cheinquer
  • P B Christensen
  • M Clausen
  • H S M Coelho
  • M E Cramp
  • G J Dore
  • W Doss
  • A S Duberg
  • M H El-Sayed
  • G Ergör
  • G Esmat
  • K Falconer
  • J Félix
  • M L G Ferraz
  • P R Ferreira
  • S Frankova
  • J García-Samaniego
  • J Gerstoft
  • J A Giria
  • F L Gonçales
  • E Gower
  • M Gschwantler
  • M Guimarães Pessôa
  • S J Hindman
  • H Hofer
  • P Husa
  • M Kåberg
  • K D E Kaita
  • A Kautz
  • S Kaymakoglu
  • M Krajden
  • H Krarup
  • W Laleman
  • D Lavanchy
  • R T Marinho
  • P Marotta
  • S Mauss
  • C Moreno
  • K Murphy
  • F Negro
  • V Nemecek
  • N Örmeci
  • A L H Øvrehus
  • J Parkes
  • K Pasini
  • K M Peltekian
  • A Ramji
  • N Reis
  • S K Roberts
  • W M Rosenberg
  • F Roudot-Thoraval
  • S D Ryder
  • R Sarmento-Castro
  • D Semela
  • M Sherman
  • G E Shiha
  • W Sievert
  • J Sperl
  • P Stärkel
  • R E Stauber
  • A J Thompson
  • P Urbanek
  • P Van Damme
  • I van Thiel
  • H Van Vlierberghe
  • D Vandijck
  • H Wedemeyer
  • N Weis
  • J Wiegand
  • A Yosry
  • A Zekry
  • M Cornberg
  • B Müllhaupt
  • C Estes
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The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. In addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing.

Original languageEnglish
JournalJournal of viral hepatitis
Volume21 Suppl 1
Pages (from-to)34-59
Number of pages26
ISSN1352-0504
DOIs
StatePublished - May 2014

    Research areas

  • Adolescent, Adult, Aged, Aged, 80 and over, Antiviral Agents, Child, Child, Preschool, Drug Therapy, Combination, Female, Global Health, Hepatitis C, Chronic, Humans, Incidence, Infant, Infant, Newborn, Male, Middle Aged, Models, Statistical, Prevalence, Young Adult

ID: 45003996