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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Filaggrin Gene Mutations and Risk of Basal Cell Carcinoma

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  1. Inter-rater agreement and reliability of outcome measurement instruments and staging systems used in hidradenitis suppurativa

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  2. Glucose metabolism in patients with psoriasis

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  3. Cause-specific mortality in patients with psoriasis and psoriatic arthritis

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  4. Prevalence of patients with self-reported hidradenitis suppurativa in a cohort of Danish blood donors: a cross-sectional study

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  1. Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

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  2. Causative exposures and temporal development of cobalt allergy in Denmark between 2002 and 2017

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  3. Diagnostic workup of occupational allergic nickel dermatitis in a nurse with multiple nickel exposures

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  4. Factors associated with patient-reported importance of skin clearance among adults with psoriasis and atopic dermatitis

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  5. Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment

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Basal cell carcinoma (BCC) is prevalent in lightly-pigmented Europeans. While ultraviolet (UV) radiation is an important risk factor, genetic predispositions to BCC have also been identified (1) . Atopic dermatitis (AD), a condition with a heritability that reaches 71-84%, might increase the risk of BCC (2) . Loss-of-function mutations in the filaggrin gene (FLG) are observed in approximately 10% of Northern Europeans and are strongly associated with AD (3) . FLG mutations lead to reduced epidermal filaggrin protein and metabolite levels, including the chromophore trans-urocanic acid (UCA) (4) . Mice with knockdown of filaggrin, or lack of functional histidase, show decreased epidermal trans-UCA levels and increased UVB-induced skin damage (5) . FLG mutation carriers also have 10% increased serum vitamin D levels suggesting increased penetration of UVB (6) . We evaluated the prevalence of FLG mutations in a cohort of patients with BCC compared to a control group from the general population in Denmark to evaluate whether FLG mutations increase the risk of BCC. This article is protected by copyright. All rights reserved.
Original languageEnglish
JournalBritish Journal of Dermatology
Volume169
Issue number5
Pages (from-to)1162-1164
ISSN0007-0963
DOIs
Publication statusPublished - 8 Aug 2013

ID: 38984945