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Natural histories of chronic obstructive pulmonary disease

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  1. Biomarkers in chronic obstructive pulmonary disease

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  1. Prognosis of COPD depends on severity of exacerbation history: A population-based analysis

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  2. Automated oxygen control with O2matic® during admission with exacerbation of COPD

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  3. Validation of lung density indices by cardiac CT for quantification of lung emphysema

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  4. Airflow limitation in people living with HIV and matched uninfected controls

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  5. Blood eosinophil count and risk of pneumonia hospitalisations in individuals with COPD

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Concepts relating to the natural history of chronic obstructive pulmonary disease (COPD) arise most importantly from the classic study of Fletcher and colleagues (The Natural History of Chronic Bronchitis and Emphysema, Oxford University Press, New York, 1976). This study, which evaluated working English men over 8 years, was used to construct a proposed life-long natural history. Although this is a classic study that has greatly advanced understanding of COPD, it has a number of limitations. Its duration is relatively short compared with the duration of COPD, so it is more cross-sectional than longitudinal. It was unable to distinguish among varied "natural histories." It assessed primarily the FEV(1), and the natural history of other features of COPD is largely undescribed. With advances in understanding the clinical features of COPD and with the development of evaluating new tools to assess patients with COPD, longitudinal studies evaluating COPD in novel ways and for longer durations are needed.
Original languageEnglish
JournalAmerican Thoracic Society. Proceedings
Volume5
Issue number9
Pages (from-to)878-83
Number of pages5
ISSN1546-3222
DOIs
Publication statusPublished - 2008

ID: 32567732