Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Rapid eye movement sleep behavior disorder and rapid eye movement sleep without atonia in narcolepsy

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Melatonin and cortisol in individuals with spinal cord injury

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Flow cytometry analysis of T-cell subsets in cerebrospinal fluid of narcolepsy type 1 patients with long-lasting disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Mortality and use of psychotropic medication in sleep apnoea patients: a population-wide register-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. A comparative study of methods for automatic detection of rapid eye movement abnormal muscular activity in narcolepsy

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Validation of a new data-driven automated algorithm for muscular activity detection in REM sleep behavior disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Melatonin and cortisol in individuals with spinal cord injury

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Type 1 narcolepsy is not present in 29 HPV-vaccinated individuals with subjective sleep complaints

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Håndtering af insomni hos voksne i almen praksis

    Research output: Contribution to journalJournal articleCommunication

  5. Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Narcolepsy is a rare disabling hypersomnia disorder that may include cataplexy, sleep paralysis, hypnagogic hallucinations, and sleep-onset rapid eye movement (REM) periods, but also disrupted nighttime sleep by nocturnal awakenings, and REM sleep behavior disorder (RBD). RBD is characterized by dream-enacting behavior and impaired motor inhibition during REM sleep (REM sleep without atonia, RSWA). RBD is commonly associated with neurodegenerative disorders including Parkinsonisms, but is also reported in narcolepsy in up to 60% of patients. RBD in patients with narcolepsy is, however, a distinct phenotype with respect to other RBD patients and characterized also by absence of gender predominance, elementary rather than complex movements, less violent behavior and earlier age at onset of motor events, and strong association to narcolepsy with cataplexy/hypocretin deficiency. Patients with narcolepsy often present dissociated sleep features including RSWA, increased density of phasic chin EMG and frequent shift from REM to NREM sleep, with or without associated clinical RBD. Most patients with narcolepsy with cataplexy lack the hypocretin neurons in the lateral hypothalamus. Tonic and phasic motor activities in REM sleep and dream-enacting behavior are mostly reported in presence of cataplexy. Narcolepsy without cataplexy is a condition rarely associated with hypocretin deficiency. We proposed that hypocretin neurons are centrally involved in motor control during wakefulness and sleep in humans, and that hypocretin deficiency causes a functional defect in the motor control involved in the development of cataplexy during wakefulness and RBD/RSWA/phasic motor activity during REM sleep.
Original languageEnglish
JournalSleep Medicine
Volume14
Issue number8
Pages (from-to)775-81
Number of pages7
ISSN1389-9457
DOIs
StatePublished - Aug 2013

ID: 42958555