Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. A catalog of genetic loci associated with kidney function from analyses of a million individuals

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Shared heritability and functional enrichment across six solid cancers

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Smoking and Increased White and Red Blood Cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. JAK2-tree: a simple CBC-based decision rule to guide appropriate JAK2 V617F mutation testing

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. AHRR (cg05575921) methylation extent of leukocyte DNA and lung cancer survival

    Research output: Contribution to journalJournal articleResearchpeer-review

  • James D McKay
  • Rayjean J Hung
  • Younghun Han
  • Xuchen Zong
  • Robert Carreras-Torres
  • David C Christiani
  • Neil E Caporaso
  • Mattias Johansson
  • Xiangjun Xiao
  • Yafang Li
  • Jinyoung Byun
  • Alison Dunning
  • Karen A Pooley
  • David C Qian
  • Xuemei Ji
  • Geoffrey Liu
  • Maria N Timofeeva
  • Stig E Bojesen
  • Xifeng Wu
  • Loic Le Marchand
  • Demetrios Albanes
  • Heike Bickeböller
  • Melinda C Aldrich
  • William S Bush
  • Adonina Tardon
  • Gad Rennert
  • M Dawn Teare
  • John K Field
  • Lambertus A Kiemeney
  • Philip Lazarus
  • Aage Haugen
  • Stephen Lam
  • Matthew B Schabath
  • Angeline S Andrew
  • Hongbing Shen
  • Yun-Chul Hong
  • Jian-Min Yuan
  • Pier Alberto Bertazzi
  • Angela C Pesatori
  • Yuanqing Ye
  • Nancy Diao
  • Li Su
  • Ruyang Zhang
  • Yonathan Brhane
  • Natasha Leighl
  • Jakob S Johansen
  • Anders Mellemgaard
  • Walid Saliba
  • Christopher A Haiman
  • Lynne R Wilkens
  • SpiroMeta Consortium
View graph of relations

Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.

Original languageEnglish
JournalNature Genetics
Volume49
Issue number7
Pages (from-to)1126-1132
Number of pages7
ISSN1061-4036
DOIs
Publication statusPublished - Jul 2017

    Research areas

  • Adenocarcinoma, Adult, Aged, Chromosome Mapping, European Continental Ancestry Group, Family Health, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Lung Neoplasms, Male, Middle Aged, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Smoking, Telomere Homeostasis, Journal Article, Meta-Analysis

ID: 52542412