Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital

Fresh-frozen plasma resuscitation after traumatic brain injury and shock attenuates extracellular nucleosome levels and deoxyribonuclease 1 depletion

Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Traumatic brain injury and shock are among the leading causes of trauma-related mortality. We have previously shown that fresh-frozen plasma (FFP) resuscitation reduces the size of brain lesion and associated swelling compared with crystalloids. We hypothesized that this effect would be associated with an attenuation of circulating nucleosome levels, a biomarker of injury with cytotoxic potential, through reconstitution of circulating deoxyribonuclease-1 (DNAse1), an enzyme identified as critical in nucleosome clearance from the circulation.
Original languageEnglish
Issue number2
Pages (from-to)197-205
Number of pages9
Publication statusPublished - Aug 2013

ID: 38918877