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Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: A randomized, sham-controlled study

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  1. Low 5-HT1B receptor binding in the migraine brain: A PET study

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  2. Altered thalamic connectivity during spontaneous attacks of migraine without aura: A resting-state fMRI study

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  3. Carbon monoxide inhalation induces headache in a human headache model

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  4. CGRP in human models of primary headaches

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  5. Changes in anxiety and depression symptoms associated to the outcome of MOH: A post-hoc analysis of the Comoestas Project

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  1. Intracranial Pressure: A Comparison of the Noninvasive HeadSense Monitor versus Lumbar Pressure Measurement

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  2. Changes in anxiety and depression symptoms associated to the outcome of MOH: A post-hoc analysis of the Comoestas Project

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  3. Cranial parasympathetic activation induces autonomic symptoms but no cluster headache attacks

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  4. Efficacy of strength training on tension-type headache: A randomised controlled study

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  • Jean Schoenen
  • Rigmor Højland Jensen
  • Michel Lantéri-Minet
  • Miguel Ja Láinez
  • Charly Gaul
  • Amy M Goodman
  • Anthony Caparso
  • Arne May
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BackgroundThe pain and autonomic symptoms of cluster headache (CH) result from activation of the trigeminal parasympathetic reflex, mediated through the sphenopalatine ganglion (SPG). We investigated the safety and efficacy of on-demand SPG stimulation for chronic CH (CCH).MethodsA multicenter, multiple CH attack study of an implantable on-demand SPG neurostimulator was conducted in patients suffering from refractory CCH. Each CH attack was randomly treated with full, sub-perception, or sham stimulation. Pain relief at 15 minutes following SPG stimulation and device- or procedure-related serious adverse events (SAEs) were evaluated.FindingsThirty-two patients were enrolled and 28 completed the randomized experimental period. Pain relief was achieved in 67.1% of full stimulation-treated attacks compared to 7.4% of sham-treated and 7.3% of sub-perception-treated attacks (p 
Original languageEnglish
JournalCephalalgia
Volume33
Issue number10
Pages (from-to)816-830
Number of pages15
ISSN0333-1024
DOIs
StatePublished - 2013

ID: 36884995