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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Determination of methyldibromoglutaronitrile in cosmetic products by high-performance liquid chromatography with electrochemical detection. Method validation

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  1. Separation of steroid isomers by ion mobility mass spectrometry

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  1. Allergic contact stomatitis caused by (meth)acrylates in an occlusal splint

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  2. Exposure analysis using X-ray fluorescence device and a cobalt spot test in four patients with cobalt allergy

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  3. Multispectral imaging of hand eczema

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  4. Effects of sampling strategy and DNA extraction on human skin microbiome investigations

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An increased frequency of contact allergy to methyldibromoglutaronitrile (MDBGN), a commonly used preservative in cosmetics and other consumer products, has been reported in recent years. A high-performance liquid chromatography (HPLC) method for the determination of MDBGN in cosmetic products has been validated in the present study. The identification is performed by reductive electrochemical detection of the bromine present in the molecule. The method is suitable for compliance testing of cosmetic products as well as for the research to support clinical and epidemiological studies.

Original languageEnglish
JournalJournal of Chromatography A
Volume1031
Issue number1-2
Pages (from-to)315-7
Number of pages3
ISSN0021-9673
Publication statusPublished - 26 Mar 2004

    Research areas

  • Calibration, Chromatography, High Pressure Liquid, Cosmetics, Dermatitis, Contact, Electrochemistry, Humans, Nitriles, Reference Standards, Reproducibility of Results, Soaps

ID: 45972790