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Variability of insulin-stimulated myocardial glucose uptake in healthy elderly subjects

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The aim of this study was to assess regional and global variability of insulin-stimulated myocardial glucose uptake in healthy elderly subjects and to evaluate potentially responsible factors. Twenty men with a mean age of 64 years, no history of cardiovascular disease, and normal blood pressure, bicycle exercise test, electrocardiogram and echocardiography were studied [ P(coronary artery disease) <5%]. Whole-body insulin sensitivity and insulin-stimulated myocardial glucose uptake were measured during hyperinsulinaemic euglycaemic glucose clamp with fluorine-18 fluorodeoxyglucose, and myocardial rest and hyperaemic blood flow during dipyridamole infusion were measured with nitrogen-13 ammonia and positron emission tomography in 16 left ventricular myocardial segments. Intra-individual and inter-individual variability of insulin-stimulated myocardial glucose uptake [relative dispersion = (standard deviation/mean)] was 13% and 29% respectively. Although inter-individual variability of glucose uptake and blood flow at rest was of the same magnitude, no correlation was found between these measures. Regional and global insulin-stimulated myocardial glucose uptake correlated linearly with whole-body insulin sensitivity ( r=0.51, P<0.05 and r=0.56, P<0.01). The strongest independent association by multivariate linear regression analysis was found between myocardial glucose uptake and hyperaemic blood flow ( r=0.63, P<0.005). We conclude that in healthy elderly subjects, insulin-stimulated myocardial glucose uptake is homogeneous throughout the left ventricle, but has moderate inter-individual variability. Inter-individual variability of insulin-stimulated myocardial glucose uptake is primarily explained by variability in coronary vascular reactivity and tissue insulin sensitivity.

Original languageEnglish
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume29
Issue number12
Pages (from-to)1600-7
Number of pages8
ISSN1619-7070
DOIs
Publication statusPublished - Dec 2002

    Research areas

  • Ammonia, Blood Glucose, Dipyridamole, Fluorodeoxyglucose F18, Glucose, Glucose Clamp Technique, Heart Ventricles, Humans, Hyperemia, Hyperinsulinism, Insulin, Male, Middle Aged, Nitrogen Radioisotopes, Radiopharmaceuticals, Reproducibility of Results, Sensitivity and Specificity, Tissue Distribution, Tomography, Emission-Computed, Ventricular Function, Left, Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't

ID: 52405866