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Exercise training induces similar elevations in the activity of oxoglutarate dehydrogenase and peak oxygen uptake in the human quadriceps muscle

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During exercise involving a small muscle mass, peak oxygen uptake is thought to be limited by peripheral factors, such as the degree of oxygen extraction from the blood and/or mitochondrial oxidative capacity. Previously, the maximal activity of the Krebs cycle enzyme oxoglutarate dehydrogenase has been shown to provide a quantitative measure of maximal oxidative metabolism, but it is not known whether the increase in this activity after a period of training reflects the elevation in peak oxygen consumption. Fourteen subjects performed one-legged knee extension exercise for 5-7 weeks, while the other leg remained untrained. Thereafter, the peak oxygen uptake by the quadriceps muscle was determined for both legs, and muscle biopsies were taken for assays of maximal enzyme activities (at 25°C). The peak oxygen uptake was 26% higher in the trained than in the untrained muscle (395 vs. 315 ml min(-1) kg(-1), respectively; P
Original languageEnglish
JournalPfluegers Archiv
Volume462
Issue number2
Pages (from-to)257-65
Number of pages9
ISSN0031-6768
DOIs
Publication statusPublished - 2011

    Research areas

  • Adult, Citric Acid Cycle, Exercise, Female, Humans, Ketoglutarate Dehydrogenase Complex, Male, Mitochondria, Oxygen Consumption, Quadriceps Muscle, Young Adult

ID: 33279793