Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The impact of storage time of transfused blood on postoperative infectious complications in rectal cancer surgery. Danish RANX05 Colorectal Cancer Study Group.

Research output: Contribution to journalReviewResearch

  1. Plasma calprotectin is superior to serum calprotectin as a biomarker of intestinal inflammation in ulcerative colitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Minimally invasive assessment of hepatic function in children with indocyanine green elimination: a validation study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Long term treatment with stimulant laxatives - clinical evidence for effectiveness and safety?

    Research output: Contribution to journalReviewResearchpeer-review

  4. Antibiotics: a risk factor for irritable bowel syndrome in a population-based cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Quality of life, performance status, and work capacity after post-endoscopic retrograde cholangiopancreatography pancreatitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Triage for selection to colonoscopy?

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Clean Colorectum at Diagnostic Colonoscopy: Subsequent Detection of Extracolonic Malignancies by Plasma Protein Biomarkers?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Circulating cell-free nucleosomes as biomarkers for early detection of colorectal cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
BACKGROUND: We have studied the impact of storage time of transfused allogeneic blood together with other known risk factors on postoperative infectious complications after operation for rectal cancer. METHODS: Intra-abdominal abscess, anastomotic leakage, septicaemia, wound infection, and pneumonia were prospectively recorded in 303 patients undergoing elective resection for primary rectal cancer in 18 Danish hospitals. Patient risk variables and variables related to operation technique and transfusion were recorded prospectively, whereas amount given before infectious complication and storage time of saline-adenine-glucose-mannitol (SAGM) blood, administered to each patient, were recorded retrospectively. RESULTS: The overall infection rate was 24% in 78 non-transfused and 40% in 225 transfused patients (P = 0.011). The proportion of SAGM blood stored for > or = 21 days administered to each transfused patient was a median of 60% in patients developing postoperative infections versus 25% (P = 0.037) in patients without infections. A multivariate analysis of significant risk variables showed weight > 75 kg (odds ratio, 2.0 versus < 65 kg) and transfusion of SAGM blood stored > or = 21 days (odds ratio, 2.5 versus no transfusion) to be independent variables predicting infectious complications. CONCLUSION: Blood storage time may, along with other risk factors, play a significant role in blood transfusion-associated development of postoperative infectious complications.
Translated title of the contributionThe impact of storage time of transfused blood on postoperative infectious complications in rectal cancer surgery. Danish RANX05 Colorectal Cancer Study Group.
Original languageEnglish
JournalScandinavian Journal of Gastroenterology
Volume35
Issue number2
Pages (from-to)212-217
Number of pages6
ISSN0036-5521
Publication statusPublished - 2000

ID: 32510306