Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

The Influence of Cyst Emptying, Lymph Node Resection and Chemotherapy on Survival in Stage IA and IC1 Epithelial Ovarian Cancer

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Hypoxia-regulated MicroRNAs in Gastroesophageal Cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. High RRM1 Expression Is Associated with Adverse Outcome in Patients with Cisplatin/Vinorelbine-treated Malignant Pleural Mesothelioma

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Methylation-associated Silencing of microRNA-126 and its Host Gene EGFL7 in Malignant Pleural Mesothelioma

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Genetic data from nearly 63,000 women of European descent predicts DNA methylation biomarkers and epithelial ovarian cancer risk

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The genetic landscape of 87 ovarian germ cell tumors

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

AIM: To determine if survival in stage I ovarian cancer is influenced by cyst emptying, lymph node resection and chemotherapy.

PATIENTS AND METHODS: A survival analysis of 607 patients with ovarian cancer in stage IA, IA with cyst emptying (IAempty) and IC1 was performed.

RESULTS: There was no difference in five-year survival between IA (87%) and IC1 (87%) (p=0.899), between IA and IAempty (86%) (p=0.500) nor between IA+IAempty (87%) and IC1 without IAempty (84%) (p=0.527). Five-year survival rate (5YSR) was significantly higher after lymph node resection in stage IA (94% vs. 85%; p=0.01) and IA+IC1 (93% vs. 85%; p=0.004). In multivariate analysis, lymph node resection improved prognosis significantly for all sub-stages, whereas stage and chemotherapy did not affect survival.

CONCLUSION: In stage IA ovarian cancer, controlled cyst emptying without spill does not worsen prognosis. Lymph node resection is associated with improved survival in stage IA and IC1. Chemotherapy should only be offered where randomized controlled studies have shown a benefit.

Original languageEnglish
JournalAnticancer Research
Volume36
Issue number10
Pages (from-to)5373-5379
Number of pages7
ISSN0250-7005
Publication statusPublished - Oct 2016

ID: 49463231