Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Reproductive function in the sons of women who experienced stress due to bereavement before and during pregnancy: a nationwide population-based cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Psychological stress, stressful life events, male factor infertility, and testicular function: a cross-sectional study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Therapeutic endometrial scratching and implantation after in vitro fertilization: a multicenter randomized controlled trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Associations of different molecular forms of antimüllerian hormone and biomarkers of polycystic ovary syndrome and normal women

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Alcohol intake in early pregnancy and spontaneous preterm birth: a cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Exploring motivations, attitudes and experiences of oocyte donors: A qualitative study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Home births-Where are we heading?

    Research output: Contribution to journalJournal articleResearch

View graph of relations

OBJECTIVE: To estimate the association between prenatal exposure to maternal stress and reproductive disorders in Danish men, where prenatal stress exposure was defined as the mother's loss of a close relative during pregnancy or in the 12 months before conception.

DESIGN: Population-based cohort study.

SETTING: Not applicable.

PATIENT(S): All males born in Denmark between 1973 and 2008 (n = 1,217,576) and observed for up to 39 years.

INTERVENTION(S): None.

MAIN OUTCOME MEASURE(S): Male reproductive function, defined using a composite outcome including congenital malformations of genital organs, testicular cancer, diagnosis of male infertility, or assisted conception use due to male factor infertility.

RESULT(S): In total, 28,986 men (2.4%) had been exposed to prenatal stress, and 62,929 (5.2%) experienced the composite outcome during the follow-up period. Prenatal exposure to stress was associated with an elevated risk of reproductive problems (hazard ratio [HR] 1.09; 95% CI, 1.04-1.15). The association was stronger when the exposure occurred during the first trimester of pregnancy, and for congenital malformations of genital organs. When focusing on infertility alone, we saw no evidence of increased risk (HR 0.90; 95% CI, 0.77-1.06). In addition, the probability of marrying a woman was lower for exposed men (HR 0.93; 95% CI, 0.89-0.98).

CONCLUSION(S): Prenatal stress in the form of the mother's bereavement during the first trimester of pregnancy is associated with a higher risk of reproductive disorders from congenital malformations of the genital organs in the male offspring. The lack of an association between maternal bereavement and later infertility in the exposed male offspring may be due in part to the men's lower probability of attempting to have children.

Original languageEnglish
JournalFertility and Sterility
Volume107
Issue number1
Pages (from-to)189-197.e8
Number of pages17
ISSN0015-0282
DOIs
Publication statusPublished - Jan 2017

ID: 49675814