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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Attenuated heart rate response in REM sleep behavior disorder and Parkinson's disease

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The objective of this study was to determine whether patients with Parkinson's disease with and without rapid-eye-movement sleep behavior disorder and patients with idiopathic rapid-eye-movement sleep behavior disorder have an attenuated heart rate response to arousals or to leg movements during sleep compared with healthy controls. Fourteen and 16 Parkinson's patients with and without rapid-eye-movement sleep behavior disorder, respectively, 11 idiopathic rapid-eye-movement sleep behavior disorder patients, and 17 control subjects underwent 1 night of polysomnography. The heart rate response associated with arousal or leg movement from all sleep stages was analyzed from 10 heartbeats before the onset of the sleep event to 15 heartbeats following onset of the sleep event. The heart rate reponse to arousals was significantly lower in both parkinsonian groups compared with the control group and the idiopathic rapid-eye-movement sleep behavior disorder group. The heart rate response to leg movement was significantly lower in both Parkinson's groups and in the idiopathic rapid-eye-movement sleep behavior disorder group compared with the control group. The heart rate response for the idiopathic rapid-eye-movement sleep behavior disorder group was intermediate with respect to the control and the parkinsonian groups. The attenuated heart rate response may be a manifestation of the autonomic deficits experienced in Parkinson's disease. The idiopathic rapid-eye-movement sleep behavior disorder patients not only exhibited impaired motor symptoms but also incipient autonomic dysfunction, as revealed by the attenuated heart rate response.
Original languageEnglish
JournalMovement Disorders
Volume27
Issue number7
Pages (from-to)888-894
Number of pages7
ISSN0885-3185
DOIs
StatePublished - 2012

    Research areas

  • Aged, Arousal, Autonomic Nervous System, Electrocardiography, Female, Heart Rate, Humans, Leg, Male, Middle Aged, Movement, Parkinson Disease, Polysomnography, REM Sleep Behavior Disorder, Reproducibility of Results, Sleep Stages

ID: 36533750