Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Reduced albuminuria during early and aggressive antihypertensive treatment of insulin-dependent diabetic patients with diabetic nephropathy

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study)

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Association Between Topical Corticosteroid Use and Type 2 Diabetes in Two European Population-Based Adult Cohorts

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Urinary albumin excretion rate (radial immunodiffusion), glomerular filtration rate (GFR) (single-shot 51Cr-EDTA technique), and arterial blood pressure (BP) were measured in 12 juvenile-onset, insulin-dependent diabetic patients with persistent proteinuria (greater than 0.5 g/day) due to diabetic nephropathy. Mean age of the patients was 30 yr. All patients had a diastolic blood pressure greater than or equal to 95 mm Hg. Metoprolol, hydralazine, and furosemide or thiazide were used as antihypertensives. During the 12-mo treatment period, BP decreased from 151/104 to 133/85 mm Hg (P less than 0.001), the urinary albumin excretion rate diminished from 1447 to 613 micrograms/min (P less than 0.005), and GFR declined from 96 to 89 ml/in/1.73 m2 (P less than 0.01). A linear relationship between mean blood pressure and the logarithm of the albuminuria was found (r = 0.48, P less than 0.01). Arterial hypertension is an early feature of diabetic nephropathy in young insulin-dependent patients. Early and aggressive treatment of that condition decreases albuminuria, probably due to reduced intraglomerular filtration pressure. Whether sustained reduction in arterial blood pressure to near-normal levels during several years also reduces the rate of decline in GFR in diabetic nephropathy remains to be established.

Original languageEnglish
JournalDiabetes Care
Volume4
Issue number4
Pages (from-to)459-63
Number of pages5
ISSN0149-5992
Publication statusPublished - 1 Jul 1981

    Research areas

  • Adult, Albuminuria, Antihypertensive Agents, Diabetes Mellitus, Type 1, Diabetic Nephropathies, Female, Humans, Hypertension, Insulin, Male, Middle Aged

ID: 44243384