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The antibody response to well-defined malaria antigens after acute malaria in individuals living under continuous malaria transmission

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  1. Lymphatic filariasis related perceptions and practices on the coast of Ghana: Implications for prevention and control

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  2. Human serum albumin and immunoglobulin on Dracunculus medinensis

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  3. Studies on immunodiagnosis of dracunculiasis. II. Search for circulating antigens

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  4. Studies on immunodiagnosis of dracunculiasis. I. Detection of specific serum antibodies

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  1. European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

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  2. Correction to: Ultra-high field MR angiography in human migraine models: a 3.0 T/7.0 T comparison study

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  3. Ultra-high field MR angiography in human migraine models: a 3.0 T/7.0 T comparison study

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  4. Hemodynamic provocation with acetazolamide shows impaired cerebrovascular reserve in adults with sickle cell disease

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  5. Gamma-aminobutyric acid edited echo-planar spectroscopic imaging (EPSI) with MEGA-sLASER at 7T

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The IgG and IgM antibody responses to the C-terminal 783 amino acids of the P. falciparum glutamate-rich protein, GLURP489-1271, expressed as an E. coli fusion protein, the IgG response to a 18-mer synthetic peptide EDKNEKGQHEIVEVEEIL (GLURP899-916) representing the C-terminal repeats of GLURP, and a synthetic peptide (EENV)6 representing the C-terminal repeats from Pf155/RESA, were investigated longitudinally in 13 children and 7 adults living under conditions of continuous, intense malaria transmission. Some subjects did not recognize the antigens after malaria infection, and in subjects recognizing the antigens, the responses were often short-lived. In adults, the antibody responses to the GLURP489-1271 fusion protein and the (EENV)6 peptide peaked after 2 weeks, and not all individuals responded to all antigens. The antibody response, even against large fragments of conserved antigens, is not uniformly elicited by natural malaria infection in previously primed donors.

Original languageEnglish
JournalActa Tropica
Volume51
Issue number2
Pages (from-to)135-42
Number of pages8
ISSN0001-706X
Publication statusPublished - Jun 1992

    Research areas

  • Adolescent, Adult, Amino Acid Sequence, Animals, Antibodies, Protozoan, Female, Humans, Immunoglobulin G, Immunoglobulin M, Malaria, Falciparum, Male, Molecular Sequence Data, Plasmodium falciparum, Protozoan Proteins

ID: 46492163