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The Capital Region of Denmark - a part of Copenhagen University Hospital

Inflammatory markers and clustered cardiovascular disease risk factors in danish adolescents

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Aims: To evaluate the associations between inflammatory markers and clustering of cardiovascular disease (CVD) risk factors, and to examine how inflammatory markers and CVD risk are related to fatness and cardiorespiratory fitness (VO(2peak)) in adolescents. Methods: Body mass and height, skinfolds and blood pressure of 413 adolescents (mean age 13.4 ± 0.3 years) were measured. Circulating fasting levels of glucose, insulin, lipids, adiponectin, C-reactive protein (CRP), tumor necrosis factor (TNF)α, soluble TNF receptor-1 (sTNFR1), interleukin (IL)-6 and IL-1 receptor antagonist (IL-1Ra) were measured. VO(2peak) was measured in progressive tests to exhaustion. CVD risk was expressed as a clustered z-score, summing standardized values of individual risk factors. Results: The clustered z-score was negatively associated with adiponectin and positively associated with CRP, IL-6 and TNFα (all p values
Original languageEnglish
JournalHormone Research in Paediatrics
Issue number5-6
Pages (from-to)288-96
Number of pages9
StatePublished - 2012

ID: 36819332