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The Capital Region of Denmark - a part of Copenhagen University Hospital
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MBL-associated serine protease-3 circulates in high serum concentrations predominantly in complex with Ficolin-3 and regulates Ficolin-3 mediated complement activation

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  1. Expression of complement C3, C5, C3aR and C5aR1 genes in resting and activated CD4+ T cells

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  2. Reconstitution of Th17, Tc17 and Treg cells after paediatric haematopoietic stem cell transplantation: Impact of interleukin-7

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  3. Alveolar recruitment of ficolin-3 in response to acute pulmonary inflammation in humans

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  4. Angiotensin II blockade, YKL-40 and maintenance of sinus rhythm after electrical cardioversion for atrial fibrillation

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  1. Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins

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  2. Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG

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  3. Expression of complement C3, C5, C3aR and C5aR1 genes in resting and activated CD4+ T cells

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  4. Human brain trauma severity is associated with lectin complement pathway activation

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  5. Amyotrophic lateral sclerosis: The complement and inflammatory hypothesis

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The human lectin complement pathway (LCP) involves circulating complexes consisting of mannose-binding lectin (MBL) or ficolins in association with serine proteases named MASP-1, -2 and -3 and a non-enzymatic protein, sMAP. MASP-3 originates from the MASP1 gene through differential splicing and little is known about its biological characteristics. For this reason we expressed recombinant MASP-3 and generated specific monoclonal antibodies to establish biochemical characteristics and to determine the serum levels, the interactions with the LCP recognition molecules and the influence on complement activation of MASP-3.
Original languageEnglish
JournalImmunobiology
Volume215
Issue number11
Pages (from-to)921-31
Number of pages11
ISSN0171-2985
DOIs
Publication statusPublished - 1 Nov 2010

ID: 32160662