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Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer

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  • Kelly L Bolton
  • Georgia Chenevix-Trench
  • Cindy Goh
  • Siegal Sadetzki
  • Susan J Ramus
  • Beth Y Karlan
  • Diether Lambrechts
  • Evelyn Despierre
  • Daniel Barrowdale
  • Lesley McGuffog
  • Sue Healey
  • Douglas F Easton
  • Olga Sinilnikova
  • Javier Benítez
  • María J García
  • Susan Neuhausen
  • Mitchell H Gail
  • Patricia Hartge
  • Susan Peock
  • Debra Frost
  • D Gareth Evans
  • Rosalind Eeles
  • Andrew K Godwin
  • Mary B Daly
  • Ava Kwong
  • Edmond S K Ma
  • Conxi Lázaro
  • Ignacio Blanco
  • Marco Montagna
  • Emma D'Andrea
  • Maria Ornella Nicoletto
  • Sharon E Johnatty
  • Susanne Krüger Kjær
  • Allan Jensen
  • Estrid Høgdall
  • Ellen L Goode
  • Brooke L Fridley
  • Jennifer T Loud
  • Mark H Greene
  • Phuong L Mai
  • Angela Chetrit
  • Flora Lubin
  • Galit Hirsh-Yechezkel
  • Gord Glendon
  • Irene L Andrulis
  • Amanda E Toland
  • Leigha Senter
  • Martin E Gore
  • Charlie Gourley
  • Caroline O Michie
  • EMBRACE
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Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear.
Original languageEnglish
JournalJ A M A: The Journal of the American Medical Association
Volume307
Issue number4
Pages (from-to)382-90
Number of pages9
ISSN0098-7484
DOIs
Publication statusPublished - 2012

    Research areas

  • Adult, Aged, Female, Genes, BRCA1, Genes, BRCA2, Germ-Line Mutation, Humans, Middle Aged, Ovarian Neoplasms, Prognosis, Survival Analysis

ID: 36785447