Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Hypnotics and mortality--partial confounding by disease, substance abuse and socioeconomic factors?

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Tramadol use in Norway: A register-based population study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Multi-centre, multi-database studies with common protocols: Lessons learnt from the IMI PROTECT project

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Use of quinine and mortality-risk in patients with heart failure-a Danish nationwide observational study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The use of valproic acid and multiple sclerosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Interpreter-mediated psychotherapy with trauma-affected refugees – A retrospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Parental socioeconomic position and midlife allostatic load: a study of potential mediators

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Early life predictors of midlife allostatic load: A prospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Young adult cognitive ability and subsequent major depression in a cohort of 666,804 Danish men

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Should benzodiazepines be avoided?

    Research output: Contribution to journalEditorialResearchpeer-review

View graph of relations

PURPOSE: The aim of this Cohort study of 10 527 Danish men was to investigate the extent to which the association between hypnotics and mortality is confounded by several markers of disease and living conditions.

METHODS: Exposure was purchases of hypnotics 1995-1999 ("low users" (150 or less defined daily dose (DDD)) or "high users" (151 or more DDD)). Follow-up for all-cause mortality was from 1 Jan 2000 to 19 June 2010. Cox proportional hazard models were used to study the association. Covariates were entered one at a time and simultaneously. Results were reported using hazard ratio (HR) and 95% confidence intervals (CI).

RESULTS: When covariates were entered one at a time, the changes in HR estimates showed that psychiatric disease, socioeconomic position and substance abuse reduced the excess risk by 17-36% in the low user group and by 45-52% in the high user group. Somatic disease, intelligence score and cohabitation reduced the excess risk by 2-11% in the low user group and 8-24% in the high user group. When adjusting for all covariates, the HR was reduced to 1.22 95% CI (0.97-1.54) in the low user group and 1.43 95% CI (1.11-1.85) in the high user group.

CONCLUSIONS: The results of this study point at psychiatric disease, substance abuse and socioeconomic position as potential confounding factors partly explaining the association between use of hypnotics and all-cause mortality.

Original languageEnglish
JournalPharmacoepidemiology and Drug Safety
Volume24
Issue number7
Pages (from-to)779-83
Number of pages5
ISSN1053-8569
DOIs
Publication statusPublished - Jul 2015

ID: 46184561