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The hydrostatic pressure indifference point underestimates orthostatic redistribution of blood in humans

Research output: Research - peer-reviewJournal article


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The hydrostatic indifference point (HIP; where venous pressure is unaffected by posture) is located at the level of the diaphragm and is believed to indicate the orthostatic redistribution of blood, but it remains unknown whether HIP coincides with the indifference point for blood volume (VIP). During graded (±20°) head-up (HUT) and head-down tilt (HDT) in 12 male volunteers we determined HIP from central venous pressure and VIP from redistribution of both blood using ultrasound imaging of the inferior caval vein (VIPui) and fluid volume by regional electrical admittance (VIPadm). Furthermore, we evaluated whether inflation of medical anti-shock trousers (to 70 mmHg) affected HIP and VIP. Leaving cardiovascular variables unaffected by tilt, HIP was located 7±4 cm (mean±SD) below the 4(th) intercostal space (IC-4) during HUT and was similar (7±3 cm) during HDT and higher (p
Original languageEnglish
JournalJournal of applied physiology (Bethesda, Md. : 1985)
Pages (from-to)730-735
StatePublished - 2014

ID: 43122059