Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Nickel acts as an adjuvant during cobalt sensitization

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. The role of skin barrier in occupational contact dermatitis

    Research output: Contribution to journalReviewResearchpeer-review

  2. Red tattoos, ultraviolet radiation and skin cancer in mice

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Skin Problems Due to Treatment with Technology Are Associated with Increased Disease Burden Among Adults with Type 1 Diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Mice with epidermal filaggrin deficiency show increased immune reactivity to nickel

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Temporal changes in chromium allergy in Denmark between 2002 and 2017

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Temporal changes in chromium allergy in Denmark between 2002 and 2017

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Increase in Vitamin D but not Regulatory T Cells following Ultraviolet B Phototherapy of Patients with Atopic Dermatitis

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Metal allergy is the most frequent form of contact allergy with nickel and cobalt being the main culprits. Typically, exposure comes from metal-alloys where nickel and cobalt co-exist. Importantly, very little is known about how co-exposure to nickel and cobalt affects the immune system. We investigated these effects by using a recently developed mouse model. Mice were epicutaneously sensitized with i) nickel alone, ii) nickel in the presence of cobalt, iii) cobalt alone, or iv) cobalt in the presence of nickel, and then followed by challenge with either nickel or cobalt alone. We found that sensitization with nickel alone induced more local inflammation than cobalt alone as measured by increased ear-swelling. Furthermore, the presence of nickel during sensitization to cobalt led to a stronger challenge response to cobalt as seen by increased ear-swelling and increased B and T cell responses in the draining lymph nodes compared to mice sensitized with cobalt alone. In contrast, the presence of cobalt during nickel sensitization only induced an increased CD8(+) T cell proliferation during challenge to nickel. Thus, the presence of nickel during cobalt sensitization potentiated the challenge response against cobalt more than the presence of cobalt during sensitization to nickel affected the challenge response against nickel. Taken together, our study demonstrates that sensitization with a mixture of nickel and cobalt leads to an increased immune response to both nickel and cobalt, especially to cobalt, and furthermore that the adjuvant effect appears to correlate with the inflammatory properties of the allergen..

Original languageEnglish
JournalExperimental Dermatology
Volume24
Issue number3
Pages (from-to)229-31
Number of pages3
ISSN0906-6705
DOIs
Publication statusPublished - Mar 2015

ID: 45118512