Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Adaptive and innate immune reactions regulating mast cell activation: from receptor-mediated signaling to responses

Research output: Contribution to journalJournal articleResearch

  1. Exercise-Induced Laryngeal Obstruction-An Overview

    Research output: Contribution to journalReviewResearchpeer-review

  2. Nonpharmacologic Strategies to Manage Exercise-Induced Bronchoconstriction

    Research output: Contribution to journalReviewResearchpeer-review

  3. Pharmacologic Strategies for Exercise-Induced Bronchospasm with a Focus on Athletes

    Research output: Contribution to journalReviewResearchpeer-review

  4. Testing for Exercise-Induced Bronchoconstriction

    Research output: Contribution to journalReviewResearchpeer-review

  5. Treatment of exercise-induced bronchoconstriction

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Beyond IgE-When Do IgE-Crosslinking and Effector Cell Activation Lead to Clinical Anaphylaxis?

    Research output: Contribution to journalReviewResearchpeer-review

  2. Bioactive small molecules in commercially available cereal food: Benzoxazinoids

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Endothelial Regulator of Calcineurin 1 Promotes Barrier Integrity and Modulates Histamine-Induced Barrier Dysfunction in Anaphylaxis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Dynamics of plasma levels of specific IgE in chlorhexidine allergic patients with and without accidental re-exposure

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Dietary exposure to benzoxazinoids enhances bacteria-induced monokine responses by peripheral blood mononuclear cells

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
In this article, we have described studies that have demonstrated that mast cells can be activated as a consequence of adaptive and innate immune reactions and that these responses can be modified by ligands for other receptors expressed on the surface of mast cells. These various stimuli differentially activate multiple signaling pathways within the mast cells required for the generation and/or release of inflammatory mediators. Thus, the composition of the suite of mediators released and the physiologic ramifications of these responses are dependent on the stimuli and the microenvironment in which the mast cells are activated. Knowledge of the different signaling molecules used by cell surface receptors may allow selective pharmacologic targeting such that inhibiting the adverse effects of mast cell activation can be achieved without influencing the beneficial effects of mast cell activation. The exact interconnections between the signaling pathways initiated by the surface receptors described in this article remain to be completely worked out; thus, this remains a topic for future investigation.
Original languageEnglish
JournalImmunology and Allergy Clinics of North America
Volume26
Issue number3
Pages (from-to)427-50
Number of pages24
ISSN0889-8561
DOIs
Publication statusPublished - 2006

    Research areas

  • Animals, Complement System Proteins, Humans, Immunity, Innate, Mast Cells, Signal Transduction, Toll-Like Receptors

ID: 33163646