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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Harnessing the beneficial properties of adipogenic microbes for improving human health

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  1. A vicious circle in chronic lymphoedema pathophysiology? An adipocentric view

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  2. Does stress influence sleep patterns, food intake, weight gain, abdominal obesity and weight loss interventions and vice versa?

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  3. Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons - a scoping review

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  1. Childhood body mass index and risk of inflammatory bowel disease in adulthood: a population-based cohort study

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  2. Change in Overweight from Childhood to Early Adulthood and Risk of Type 2 Diabetes

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  3. Prospective studies exploring the possible impact of an ID3 polymorphism on changes in obesity measures

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  4. BMI at school age and incident asthma admissions in early adulthood: a prospective study of 310,211 children

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  • N V Dhurandhar
  • L Geurts
  • R L Atkinson
  • L Casteilla
  • K Clement
  • P Gerard
  • M Vijay-Kumar
  • J H Nam
  • M Nieuwdorp
  • G Trovato
  • T I A Sørensen
  • A Vidal-Puig
  • P D Cani
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Obesity is associated with numerous metabolic comorbidities. Weight loss is an effective measure for alleviating many of these metabolic abnormalities. However, considering the limited success of most medical weight-management approaches in producing a sustained weight loss, approaches that improve obesity-related metabolic abnormalities independent of weight loss would be extremely attractive and of practical benefit. Metabolically healthy obesity supports the notion that a better metabolic profile is possible despite obesity. Moreover, adequate expansion of adipose tissue appears to confer protection from obesity-induced metabolic comorbidities. To this end, the 10th Stock conference examined new approaches to improve metabolic comorbidities independent of weight loss. In particular, human adenovirus 36 (Ad36) and specific gut microbes were examined for their potential to influence lipid and glucose homeostasis in animals and humans. While these microbes possess some undesirable properties, research has identified attributes of adenovirus Ad36 and gut microbes that may be selectively harnessed to improve metabolic profile without the obligatory weight loss. Furthermore, identifying the host signalling pathways that these microbes recruit to improve the metabolic profile may offer new templates and targets, which may facilitate the development of novel treatment strategies for obesity-related metabolic conditions.
Original languageEnglish
JournalObesity reviews : an official journal of the International Association for the Study of Obesity
Volume14
Issue number9
Pages (from-to)721-35
Number of pages15
ISSN1467-7881
DOIs
StatePublished - Sep 2013

ID: 42694064