Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Soluble Interleukin-7 receptor levels and risk of acute graft-versus-disease after allogeneic haematopoietic stem cell transplantation

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Novel CFI mutation in a patient with leukocytoclastic vasculitis may redefine the clinical spectrum of Complement Factor I deficiency

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The lectin pathway of complement: advantage or disadvantage in HIV pathogenesis?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Pre-transplant levels of ficolin-3 are associated with kidney graft survival

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Adjuvanted HLA-supertype restricted subdominant peptides induce new T-cell immunity during untreated HIV-1-infection

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Evaluation of algorithm development approaches: Development of biomarker panels for early detection of colorectal lesions

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Prognostic factors for relapse in patients with clinical stage I testicular cancer: protocol for a Danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Prognostic factors for relapse in patients with clinical stage I testicular cancer: protocol for a Danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Mandibular advancement device therapy for obstructive sleep apnea: a prospective study on predictors of treatment success

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Interleukin-7 is a cytokine essential for T cell homeostasis. IL-7 binds to cellular IL-7 receptors in competition with a soluble form of the receptor (sIL-7Rα). We hypothesized that altered sIL-7Rα levels may cause adverse outcomes in patients undergoing HSCT. In parallel, we investigated the impact of the IL-7Rα SNP rs6897932, which has been associated with release of IL-7R. The sIL-7Rα levels decreased during HSCT (from 114ng/ml before to 48ng/ml at day +14 (P<0.0001)). This pattern was inversely mirrored by IL-7. The IL-7/sIL-7Rα ratio at day +14 was significantly higher in patients developing grade II-IV aGVHD (OR=4.3, P=0.026). Furthermore, donor carriage of the rs6897932 T allele was associated with reduced sIL-7Rα levels, increased risk of grade II-IV aGVHD (OR=2.4, P=0.055) and increased transplant-related mortality (CC=4.5%, CT=21.4% and TT=27.3%, P=0.0037). In conclusion, this study suggests an impact of sIL-7Rα levels and rs6897932 donor genotype on alloreactivity and outcome after HSCT.

Original languageEnglish
JournalClinical immunology (Orlando, Fla.)
Volume187
Pages (from-to)26-32
ISSN1521-6616
DOIs
Publication statusPublished - Feb 2018

    Research areas

  • Journal Article

ID: 51664115