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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Vigabatrin in childhood epilepsy: a 5-year follow-up study

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In an retrospective uncontrolled long-term study in 30 children with intractable epilepsy, it was found that treatment with vigabatrin resulted in a seizure reduction of more than 50% at 1-year follow-up in 40% of the children. The responders were all children with partial seizures. Side effects were mild and did not lead to discontinuation of the drug. Increased numbers of seizures were seen in three cases. A moderate weight increase was seen in 27% of the children. At 5-year follow-up 7 children (23%) still maintained a seizure reduction of more than 50%. Trials of monotherapy in three seizure-free patients were unsuccessful. No further side effects were observed. A study of evoked potentials in 12 children showed no alteration in latency and amplitudes of VEP following treatment with vigabatrin. Our results show that in children vigabatrin seems to have a stable effect even though a few children may experience a breakthrough of seizures. The presented results together with previous reports on MRI-scans seem to indicate that even in children with a still maturing CNS vigabatrin is a safe drug.
Original languageEnglish
JournalNeuropediatrics
Volume26
Issue number5
Pages (from-to)253-6
Number of pages4
ISSN0174-304X
DOIs
Publication statusPublished - 1995

    Research areas

  • Adolescent, Anticonvulsants, Child, Child, Preschool, Epilepsy, Evoked Potentials, Auditory, Brain Stem, Evoked Potentials, Visual, Female, Follow-Up Studies, Humans, Male, Retrospective Studies, Vigabatrin, gamma-Aminobutyric Acid

ID: 36737296