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Interactions of the humoral pattern recognition molecule PTX3 with the complement system

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  1. Expression of complement C3, C5, C3aR and C5aR1 genes in resting and activated CD4+ T cells

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  2. Reconstitution of Th17, Tc17 and Treg cells after paediatric haematopoietic stem cell transplantation: Impact of interleukin-7

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  3. Alveolar recruitment of ficolin-3 in response to acute pulmonary inflammation in humans

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  4. Angiotensin II blockade, YKL-40 and maintenance of sinus rhythm after electrical cardioversion for atrial fibrillation

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  1. Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine

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  2. The impact of mannose-binding lectin polymorphisms on lung function in primary ciliary dyskinesia

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  3. Plasma levels of mannose-binding lectin and future risk of venous thromboembolism

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  • Andrea Doni
  • Cecilia Garlanda
  • Barbara Bottazzi
  • Seppo Meri
  • Peter Garred
  • Alberto Mantovani
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The innate immune system comprises a cellular and a humoral arm. The long pentraxin PTX3 is a fluid phase pattern recognition molecule, which acts as an essential component of the humoral arm of innate immunity. PTX3 has antibody-like properties including interactions with complement components. PTX3 interacts with C1q, ficolin-1 and ficolin-2 as well as mannose-binding lectin, recognition molecules in the classical and lectin complement pathways. The formation of these heterocomplexes results in cooperative pathogen recognition and complement activation. Interactions with C4b binding protein and factor H, the principal regulators of the classical, lectin and alternative complement pathways, show that PTX3 also may have a major influence on the regulation of the complement system. The complex interaction of PTX3 with the complement system at different levels has broad implications for host defence and regulation of inflammation.
Original languageEnglish
JournalImmunobiology
Volume217
Issue number11
Pages (from-to)1122-8
Number of pages7
ISSN0171-2985
DOIs
Publication statusPublished - 2012

ID: 36331255