Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Description and validation of a new automated surveillance system for Clostridium difficile in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hepatitis B virus in drug users in France: prevalence and vaccination history, ANRS-Coquelicot Survey 2011-2013

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. A case-control study of risk factors for rotavirus infections in adults, Denmark, 2005-2009

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Seroincidence of non-typhoid Salmonella infections: convenience vs. random community-based sampling

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The diagnosis and treatment of Helicobacter pylori infection in Arctic regions with a high prevalence of infection: Expert Commentary

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Risk Prediction of Atrial Fibrillation Based on Electrocardiographic Interatrial Block

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Risk of incident atrial fibrillation in patients presenting with retinal artery or vein occlusion: a nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Airflow limitation in people living with HIV and matched uninfected controls

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Severity of chronic obstructive pulmonary disease and presenting rhythm in patients with out-of-hospital cardiac arrest

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
SUMMARY The antibiotic trimethoprim acts as a folate antagonist. Since trophoblasts are very sensitive to drugs that interfere with the folic acid cycle and thereby inhibit DNA synthesis, use of trimethoprim during the first trimester could be associated with miscarriage. A nationwide cohort study including all women in Denmark with a registered pregnancy between 1997 and 2005 was conducted. We used nationwide registers to identify all women giving birth, having a record of miscarriage or induced abortion. Data on exposure to trimethoprim were obtained from the National Prescription Register. Cox proportional hazard regression analysis with exposure to trimethoprim as a time-dependent variable was used to estimate the risk of miscarriage. The adjusted hazard ratio of having a miscarriage after exposure to trimethoprim in the first trimester compared to non-exposure was 2·04 (95% confidence interval 1·43-2·91). Our results indicate that trimethoprim exposure in the first trimester is associated with a doubling of the hazard of miscarriage.
Original languageEnglish
JournalEpidemiology and Infection
Pages (from-to)1-7
Number of pages7
ISSN0950-2688
DOIs
StatePublished - 2012

ID: 36469874