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Activation of endogenous retrovirus reverse transcriptase in multiple sclerosis patient lymphocytes by inactivated HSV-1, HHV-6 and VZV

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  1. B cells from patients with multiple sclerosis have a pathogenic phenotype and increased LTα and TGFβ1 response

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  2. Inflammatory markers of CHMP2B-mediated frontotemporal dementia

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  3. Characterization of naïve, memory and effector T cells in progressive multiple sclerosis

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  4. Immunological effects of methylprednisolone pulse treatment in progressive multiple sclerosis

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  1. Inflammatory bowel disease increases the risk of Parkinson's disease: a Danish nationwide cohort study 1977-2014

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  2. Changes in the cell population in brain white matter in multiple system atrophy

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  3. Autoimmune antibody decline in Parkinson's disease and Multiple System Atrophy; a step towards immunotherapeutic strategies

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  • Tomasz Brudek
  • Pernille Lühdorf
  • Tove Christensen
  • Hans Jacob Hansen
  • Anné Møller-Larsen
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Human endogenous retroviruses (HERVs) and herpesviruses have been associated with the development of multiple sclerosis (MS). These virus groups interact with each other and have been shown to induce synergistic immune responses. Here, we focus on the possible role of herpesviruses as contributing factors in HERV activation. We demonstrate the ability of HSV-1, HHV-6, and VZV antigens to induce higher RT activity in peripheral lymphocytes from MS patients vs. controls during the first 6 days post-antigen stimulation. On subsequent days, only VZV can sustain the increase in the RT expression in cells from MS patients. The RT induction does not depend on herpes replication.

Original languageEnglish
JournalJournal of Neuroimmunology
Volume187
Issue number1-2
Pages (from-to)147-55
Number of pages9
ISSN0165-5728
DOIs
Publication statusPublished - Jul 2007

    Research areas

  • Adult, Antigens, Viral, Cell Proliferation, Dose-Response Relationship, Immunologic, Endogenous Retroviruses, Enzyme Activation, Female, Gene Expression Regulation, Viral, Herpesvirus 1, Human, Herpesvirus 3, Human, Herpesvirus 6, Human, Humans, Lymphocyte Activation, Lymphocytes, Male, Middle Aged, Multiple Sclerosis, RNA-Directed DNA Polymerase, Reverse Transcriptase Polymerase Chain Reaction, Time Factors, Virus Activation, Journal Article, Research Support, Non-U.S. Gov't

ID: 50616114