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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Treatment of micro air bubbles in rat adipose tissue at 25 kPa altitude exposures with perfluorocarbon emulsions and nitric oxide

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  1. Biomechanical properties of the patellar tendon in children with heritable connective tissue disorders

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  2. Effects of recreational football on women's fitness and health: adaptations and mechanisms

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  3. Beta2-adrenergic stimulation increases energy expenditure at rest, but not during submaximal exercise in active overweight men

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  1. Neuronal nitric oxide inhibition attenuates the protective effect of HBO2 during cyanide poisoning

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  2. Pivotal Role of Preexisting Pathogen-Specific Antibodies in the Development of Necrotizing Soft-Tissue Infections

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  3. Forensic Case Reports Presenting Immersion Pulmonary Edema as a Differential Diagnosis in Fatal Diving Accidents

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  4. Necrotizing soft tissue infections - a multicentre, prospective observational study (INFECT): protocol and statistical analysis plan

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  5. Protein SIC Secreted fromForms Complexes with Extracellular Histones That Boost Cytokine Production

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Perfluorocarbon emulsions (PFC) and nitric oxide (NO) releasing agents have on experimental basis demonstrated therapeutic properties in treating and preventing the formation of venous gas embolism as well as increased survival rate during decompression sickness from diving. The effect is ascribed to an increased solubility and transport capacity of respiratory gases in the PFC emulsion and possibly enhanced nitrogen washout through NO-increased blood flow rate and/or the removal of endothelial micro bubble nuclei precursors. Previous reports have shown that metabolic gases (i.e., oxygen in particular) and water vapor contribute to bubble growth and stabilization during altitude exposures. Accordingly, we hypothesize that the administration of PFC and NO donors upon hypobaric pressure exposures either (1) enhance the bubble disappearance rate through faster desaturation of nitrogen, or in contrast (2) promote bubble growth and stabilization through an increased oxygen supply.
Original languageEnglish
JournalEuropean Journal of Applied Physiology
Volume114
Issue number1
Pages (from-to)135-46
ISSN1439-6319
DOIs
StatePublished - 2014

ID: 41960978