Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Asthma severity and fertility outcome in women with polycystic ovary syndrome: a registry-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. FeNO-based asthma management results in faster improvement of airway hyperresponsiveness

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Sharing and reuse of individual participant data from clinical trials: principles and recommendations

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Early vasopressor use following traumatic injury: a systematic review

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Association of alcohol consumption with allergic disease and asthma: a multicenter Mendelian Randomization analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Increased frequency of rare missense PPP1R3B variants among Danish patients with type 2 diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Richard W Morris
  • Amy E Taylor
  • Meg E Fluharty
  • Johan H Bjørngaard
  • Bjørn Olav Åsvold
  • Maiken Elvestad Gabrielsen
  • Archie Campbell
  • Riccardo Marioni
  • Meena Kumari
  • Tellervo Korhonen
  • Satu Männistö
  • Pedro Marques-Vidal
  • Marika Kaakinen
  • Alana Cavadino
  • Iris Postmus
  • Lise Lotte N Husemoen
  • Tea Skaaby
  • Tarun Veer Singh Ahluwalia
  • Jorien L Treur
  • Gonneke Willemsen
  • Caroline Dale
  • S Goya Wannamethee
  • Jari Lahti
  • Aarno Palotie
  • Katri Räikkönen
  • Alex McConnachie
  • Sandosh Padmanabhan
  • Andrew Wong
  • Christine Dalgård
  • Lavinia Paternoster
  • Yoav Ben-Shlomo
  • Jessica Tyrrell
  • John Horwood
  • David M Fergusson
  • Martin A Kennedy
  • Ellen A Nohr
  • Lene Christiansen
  • Kirsten Ohm Kyvik
  • Diana Kuh
  • Graham Watt
  • Johan G Eriksson
  • Peter H Whincup
  • Jacqueline M Vink
  • Dorret I Boomsma
  • George Davey Smith
  • Debbie Lawlor
  • Allan Linneberg
  • Ian Ford
  • J Wouter Jukema
  • Chris Power
  • Elina Hyppönen
  • Marjo-Riitta Jarvelin
  • Martin Preisig
  • Katja Borodulin
  • Jaakko Kaprio
  • Mika Kivimaki
  • Blair H Smith
  • Caroline Hayward
  • Pål R Romundstad
  • Thorkild I A Sørensen
  • Marcus R Munafò
  • Naveed Sattar
View graph of relations

OBJECTIVES: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity.

DESIGN: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes.

PARTICIPANTS: 148 731 current, former and never-smokers of European ancestry aged ≥16 years from 29 studies in the consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA).

PRIMARY OUTCOME MEASURES: Waist and hip circumferences, and waist-hip ratio.

RESULTS: The data included up to 66 809 never-smokers, 43 009 former smokers and 38 913 current daily cigarette smokers. Among current smokers, for each extra minor allele, the geometric mean was lower for waist circumference by -0.40% (95% CI -0.57% to -0.22%), with effects on hip circumference, waist-hip ratio and body mass index (BMI) being -0.31% (95% CI -0.42% to -0.19), -0.08% (-0.19% to 0.03%) and -0.74% (-0.96% to -0.51%), respectively. In contrast, among never-smokers, these effects were higher by 0.23% (0.09% to 0.36%), 0.17% (0.08% to 0.26%), 0.07% (-0.01% to 0.15%) and 0.35% (0.18% to 0.52%), respectively. When adjusting the three central adiposity measures for BMI, the effects among current smokers changed direction and were higher by 0.14% (0.05% to 0.22%) for waist circumference, 0.02% (-0.05% to 0.08%) for hip circumference and 0.10% (0.02% to 0.19%) for waist-hip ratio, for each extra minor allele.

CONCLUSIONS: For a given BMI, a gene variant associated with increased cigarette consumption was associated with increased waist circumference. Smoking in an effort to control weight may lead to accumulation of central adiposity.

Original languageEnglish
JournalB M J Open
Volume5
Issue number8
Pages (from-to)e008808
ISSN2044-6055
DOIs
StatePublished - 2015

ID: 45553812