Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Urinary growth hormone excretion in 657 healthy children and adults: normal values, inter- and intraindividual variations

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Aortic dimensions in girls and young women with Turner syndrome - a magnetic resonance imaging study

    Research output: Contribution to journalConference articleResearchpeer-review

  2. Bridging provocative tests and clinical manifestations of growth hormone deficiency in adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Low birth weight and male reproductive function

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Metabolic aspects of insulin resistance in individuals born small for gestational age

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Distinguishing between hidden testes and anorchia: The role of endocrine evaluation in infancy and childhood

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Use of stored serum in the study of time trends and geographical differences in exposure of pregnant women to phthalates

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Sex-specific estrogen levels and reference intervals from infancy to late adulthood determined by LC-MS/MS

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Urinary growth hormone (u-GH) excretion was measured in 547 healthy children and 110 adults by ELISA with a detection limit of 1.1 ng/l u-GH after prior concentration of the urine samples (20- to 30-fold). u-GH excretion values were significantly dependent on the pubertal stage (p less than 0.0001) with maximum values in Tanner stage 3 for girls and 4 for boys. This corresponded to a peak in u-GH excretion between 11.5-14.5 years in girls and 12.5-16 years in boys. Additionally, u-GH excretion in adults was significantly higher than in prepubertal children (p less than 0.001). The day/night ratio of u-GH excretion (pg/h) was significantly higher in females than in males (p less than 0.01). In Tanner stages 1-4, u-GH excretion during the day was lower than that at night, whereas the opposite was true in late puberty and in adult women. The interindividual variation of u-GH excretion within the same Tanner stage was considerable and approximately double the intraindividual variation. The day-to-day variation could be further reduced by collection of three consecutive urine samples. The variations were larger if night samples instead of 24-hour samples were considered. The expression of u-GH excretion in nanograms per gram creatinine did not diminish the observed variation and blunted the pubertal increase in u-GH excretion. In conclusion, (1) u-GH excretion depends significantly on age, sex and pubertal maturation as does the day/night ratio of u-GH excretion. (2) The interindividual variation in u-GH excretion is considerable.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish
JournalHormone Research
Volume36
Issue number5-6
Pages (from-to)174-82
Number of pages9
ISSN0301-0163
Publication statusPublished - 1991

    Research areas

  • Adolescent, Adult, Child, Circadian Rhythm, Cross-Sectional Studies, Denmark, Female, Growth Hormone, Humans, Longitudinal Studies, Male, Puberty, Reference Values, Sex Characteristics

ID: 44937224