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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Effect of cimetidine on survival after gastric cancer

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  1. Colorectal Cancer in Individuals With Familial Adenomatous Polyposis, Based on Analysis of the Danish Polyposis Registry

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  2. A proposed staging system and stage-specific interventions for familial adenomatous polyposis

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  3. Local involvement of the lower urinary tract in primary colorectal cancer - outcome after en-bloc resection

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  4. Transanal endoscopic microsurgery for giant polyps of the rectum

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  5. The outcome of rectal cancer after early salvage TME following TEM compared with primary TME: a case-matched study

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The effect of cimetidine on survival was investigated in 181 patients with gastric cancer. Immediately after operation or the decision not to operate, the patients were randomised in double-blind fashion to placebo or cimetidine 400 mg twice daily for two years or until death, with review every three months. Median survival in the cimetidine group was 450 days (range 1-1826) and in the placebo group 316 days (1-1653). The relative survival rates (cimetidine/placebo) were 45%/28% at 1 year, 22%/13% at 2 years, 13%/7% at 3 years, 9%/3% at 4 years, and 2%/0% at 5 years. Survival in the cimetidine group was significantly longer than in the placebo group.

Original languageEnglish
JournalLancet
Volume2
Issue number8618
Pages (from-to)990-992
Number of pages3
ISSN0140-6736
Publication statusPublished - 29 Oct 1988

    Research areas

  • Actuarial Analysis, Adult, Aged, Aged, 80 and over, Cimetidine, Clinical Trials as Topic, Denmark, Double-Blind Method, Drug Evaluation, Female, Humans, Male, Middle Aged, Multicenter Studies as Topic, Neoplasm Staging, Prognosis, Prospective Studies, Random Allocation, Retrospective Studies, Stomach Neoplasms, Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial

ID: 32522129