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Apparently conclusive meta-analyses may be inconclusive--Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses

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Random error may cause misleading evidence in meta-analyses. The required number of participants in a meta-analysis (i.e. information size) should be at least as large as an adequately powered single trial. Trial sequential analysis (TSA) may reduce risk of random errors due to repetitive testing of accumulating data by evaluating meta-analyses not reaching the information size with monitoring boundaries. This is analogous to sequential monitoring boundaries in a single trial.
Original languageEnglish
JournalInternational Journal of Epidemiology
Volume38
Issue number1
Pages (from-to)287-98
Number of pages12
ISSN0300-5771
DOIs
Publication statusPublished - Feb 2009

    Research areas

  • Data Interpretation, Statistical, Humans, Infant, Newborn, Infant, Newborn, Diseases, Meta-Analysis as Topic, Randomized Controlled Trials as Topic, Review Literature as Topic, Sample Size

ID: 38923291